{"id":"W2909844946","doi":"10.1016/j.chom.2018.12.008","title":"HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; Canadian Institutes of Health Research; Massachusetts General Hospital; National Cancer Institute; National Institutes of Health; EMBO; California Department of Fish and Game","keywords":"Biology; Cytoskeleton; Cell biology; Motility; Actin; Actin cytoskeleton; Cell migration; Chemokine; Virus; Immune system; Chemokine receptor; Virology; Cell; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002363971,0.0002269107,0.000260125,0.00004603692,0.000239238,0.00003902939,0.000319804,0.0001628711,0.0005187236],"category_scores_gemma":[0.000008146882,0.0001213641,0.0001042038,0.0001147539,0.0002819345,0.00008354412,0.0001368505,0.000368695,0.0009382981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003035584,"about_ca_system_score_gemma":0.00005074644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002365167,"about_ca_topic_score_gemma":0.000029377,"domain_scores_codex":[0.9986676,0.0002180604,0.0002367464,0.0003354018,0.00006301963,0.000479157],"domain_scores_gemma":[0.9990649,0.0003455885,0.000115714,0.0003767578,0.00005524206,0.00004183416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003770203,0.0001732666,0.05019359,0.00009637648,0.00005610841,0.000005310096,0.001981128,0.000001753153,0.9401525,0.000009910606,0.0006712852,0.006281744],"study_design_scores_gemma":[0.002097657,0.0003545405,0.1976805,0.0001112192,0.00005896661,0.00002361431,0.0006989496,0.000002018544,0.7626576,0.000002610986,0.03611841,0.0001939063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800743,0.01649554,0.0000152983,0.0006349312,0.0001645637,0.0005970777,0.0002172287,0.0000191224,0.001781971],"genre_scores_gemma":[0.9934651,0.0007748253,0.00002858018,0.00007491366,0.00002411132,0.00003330352,0.00008899674,0.00002261903,0.005487565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1774949,"threshold_uncertainty_score":0.9998396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005992613574547046,"score_gpt":0.2200363106987068,"score_spread":0.2140436971241598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}