{"id":"W2909847838","doi":"10.3390/biom9010029","title":"Impact of p85α Alterations in Cancer","year":2019,"lang":"en","type":"review","venue":"Biomolecules","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Cancer Agency","keywords":"PTEN; Tensin; P110α; PI3K/AKT/mTOR pathway; Protein subunit; Biology; GTPase; Phosphatase; Cell biology; Gene isoform; Phosphoinositide 3-kinase; Small GTPase; Signal transduction; Genetics; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003215166,0.0006033662,0.0008164116,0.001343067,0.0001886294,0.0005559381,0.00052524,0.0008584101,0.002459282],"category_scores_gemma":[0.0003758508,0.0001927487,0.0002908752,0.001075633,0.0002624967,0.0006182465,0.0004776011,0.001252431,0.00185896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005307604,"about_ca_system_score_gemma":0.0006201116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007783285,"about_ca_topic_score_gemma":0.001414115,"domain_scores_codex":[0.9998938,0.00001505776,0.0000152244,0.00002361477,0.00004002781,0.00001225376],"domain_scores_gemma":[0.9998821,0.00004895337,0.00001650577,0.00000419857,0.00003515359,0.0000130908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007875301,0.00004022709,0.0001798131,0.009542278,0.00007413579,0.0002421861,0.0000304486,0.0002864595,0.002331826,0.003006521,0.03183354,0.9523538],"study_design_scores_gemma":[0.00001248478,0.00007347178,0.0008694382,0.001454236,0.00008354697,0.001648094,0.00002433021,0.00006174594,0.0007833287,0.001117706,0.993861,0.00001079421],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001580629,0.9978941,0.00008250267,0.0002290321,0.0002129114,0.000003029231,0.00001800336,0.000008368843,0.001394069],"genre_scores_gemma":[0.001136531,0.9971294,0.000123729,0.0002747156,0.0001584431,0.000004676908,0.00004249414,0.000002178832,0.001127979],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002459282,"threshold_uncertainty_score":0.00822711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06919782603197913,"score_gpt":0.4324640918458669,"score_spread":0.3632662658138878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}