{"id":"W2909969157","doi":"10.1172/jci.insight.123431","title":"BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"RIKEN; University of British Columbia; Capital Medical University; National Natural Science Foundation of China; RIKEN Brain Science Institute; Canadian Institutes of Health Research; Alzheimer Society; National Science Foundation","keywords":"Pathogenesis; Amyloid precursor protein secretase; Clusterin; Amyloid precursor protein; Senile plaques; Neuropathology; Presenilin; Alzheimer's disease; P3 peptide; Cell biology; Biochemistry of Alzheimer's disease; Chemistry; Biology; Neuroscience; Medicine; Disease; Internal medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930296,0.0006128623,0.0003301112,0.0003598919,0.0002788797,0.0003826244,0.0002462272,0.0003898368,0.001461757],"category_scores_gemma":[0.000147488,0.0001812041,0.0002188908,0.000177081,0.0003440366,0.0002567246,0.0004105724,0.0005337106,0.0003625508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002657692,"about_ca_system_score_gemma":0.0001983593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006046866,"about_ca_topic_score_gemma":0.0007151687,"domain_scores_codex":[0.9998914,0.00001826012,0.00001031343,0.00002657718,0.00003401044,0.0000193629],"domain_scores_gemma":[0.9998986,0.00001156773,0.00002151283,0.00001173628,0.00001523895,0.00004145702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002265148,0.00003325606,0.0004769189,0.00004858205,0.00001147636,0.0003019646,0.0000189285,0.00004619151,0.9969626,0.0002925812,0.0001277688,0.00145311],"study_design_scores_gemma":[0.00007129164,0.0003057676,0.0115972,0.00001757746,0.00006815353,0.003423483,0.00006836829,0.001494189,0.9683053,0.000327488,0.01430586,0.00001529719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830287,0.005231747,0.006125897,0.0004386613,0.0001192734,0.00005947722,0.0006842931,0.0002454926,0.004066568],"genre_scores_gemma":[0.9908345,0.001906494,0.002446004,0.0001051542,0.00003306816,0.000031817,0.0005380283,0.00003436192,0.004070641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461757,"threshold_uncertainty_score":0.004890025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362658799629497,"score_gpt":0.2905284078576635,"score_spread":0.2669018198613685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}