{"id":"W2909969157","doi":"10.1172/jci.insight.123431","title":"BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"RIKEN; University of British Columbia; Capital Medical University; National Natural Science Foundation of China; RIKEN Brain Science Institute; Canadian Institutes of Health Research; Alzheimer Society; National Science Foundation","keywords":"Pathogenesis; Amyloid precursor protein secretase; Clusterin; Amyloid precursor protein; Senile plaques; Neuropathology; Presenilin; Alzheimer's disease; P3 peptide; Cell biology; Biochemistry of Alzheimer's disease; Chemistry; Biology; Neuroscience; Medicine; Disease; Internal medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001142408,0.0002233543,0.0004111343,0.0002108424,0.00006198342,0.00002242694,0.0001349428,0.0001032491,0.002763651],"category_scores_gemma":[0.0002764353,0.0002016102,0.0001766,0.0002648039,0.00007928906,0.00007125887,0.0001502199,0.0001223914,0.002186758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008129157,"about_ca_system_score_gemma":0.0002336659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005348339,"about_ca_topic_score_gemma":0.000003990133,"domain_scores_codex":[0.9984465,0.00008056243,0.0003102617,0.0004915618,0.0003146948,0.0003564216],"domain_scores_gemma":[0.9983176,0.0001901221,0.00006593292,0.000622531,0.0001844087,0.0006193876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005323249,0.001935398,0.7463108,0.0004207849,0.001032465,0.003419045,0.0003854446,0.00009026822,0.06431979,0.02544308,0.1488016,0.002518059],"study_design_scores_gemma":[0.002846743,0.000250914,0.8427575,0.000110116,0.0005624224,0.00005927242,0.00003182178,0.0001422091,0.001781745,0.001802963,0.1493508,0.0003034527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836056,0.002726018,0.0004145554,0.004889783,0.0006701163,0.001437356,0.0006320935,0.0001521224,0.005472415],"genre_scores_gemma":[0.9887336,0.00001855144,0.0005791873,0.008483525,0.0002212287,0.0001965313,0.0006456939,0.0000436622,0.001077942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09644672,"threshold_uncertainty_score":0.9985902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362658799629497,"score_gpt":0.2905284078576635,"score_spread":0.2669018198613685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}