{"id":"W2909991553","doi":"10.1136/annrheumdis-2018-eular.2134","title":"AB0939 Off-label secukinumab dose escalation in the treatment of moderate-to-severe psoriasis: a multicenter, retrospective study","year":2018,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Health Sciences Centre; NOSM University; Sunnybrook Health Science Centre; Western University; McMaster University; University of Toronto","funders":"","keywords":"Secukinumab; Medicine; Psoriasis; Psoriatic arthritis; Dosing; Psoriasis Area and Severity Index; Retrospective cohort study; Adverse effect; Internal medicine; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002321805,0.0005494517,0.00112535,0.0004003727,0.0004182826,0.001067227,0.0004471685,0.0005617435,0.001170444],"category_scores_gemma":[0.002745874,0.0004334645,0.00148555,0.0009011496,0.0008251502,0.0007409387,0.0003537281,0.0008019831,0.0002641693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005811415,"about_ca_system_score_gemma":0.000592728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006693464,"about_ca_topic_score_gemma":0.0006861358,"domain_scores_codex":[0.9973008,0.001064247,0.000399184,0.0006452454,0.0003868869,0.0002036358],"domain_scores_gemma":[0.9972613,0.000572514,0.001090799,0.000495483,0.0003034916,0.0002764169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08856877,0.003763495,0.8612958,0.0005869072,0.005313545,0.0009503922,0.000654458,0.0004606189,0.008470721,0.0002426568,0.00060219,0.02909051],"study_design_scores_gemma":[0.007107573,0.04115045,0.9357902,0.0001102426,0.006413993,0.002385727,0.0006485874,0.001019187,0.001704825,0.0001726309,0.003417276,0.00007938115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982418,0.0009617943,0.0002210537,0.00002060155,0.00001783482,0.0000856955,0.0001241133,0.000003682276,0.0003233482],"genre_scores_gemma":[0.9990203,0.0002382044,0.0001780893,0.00008080588,0.00004213878,0.00004298892,0.0002779455,0.000005140962,0.0001143528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002321805,"threshold_uncertainty_score":0.01227903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1059211292641976,"score_gpt":0.4121916472936245,"score_spread":0.3062705180294269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}