{"id":"W2909995258","doi":"10.14232/phd.10059","title":"Investigation of antiarrhythmic and proarrhythmic mechanisms in modified systems with molecular biological methods","year":2019,"lang":"en","type":"dissertation","venue":"","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Electrophysiology; Cardiac electrophysiology; Induced pluripotent stem cell; Membrane potential; Cardiology; Inward-rectifier potassium ion channel; Patch clamp; Ion channel; Internal medicine; Chemistry; Biophysics; Biomedical engineering; Pharmacology; Medicine; Biology; Receptor; Biochemistry; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000371711,0.0002856369,0.0002480728,0.0001778541,0.0001018299,0.000426257,0.0004019151,0.0004567413,0.001654742],"category_scores_gemma":[0.000331828,0.0001315407,0.0003631567,0.000133516,0.0002828856,0.0005650295,0.0002229301,0.0006064291,0.0005177176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944592,"about_ca_system_score_gemma":0.0001278797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001027369,"about_ca_topic_score_gemma":0.000122659,"domain_scores_codex":[0.9998283,0.00003134329,0.00001216987,0.00004442308,0.00006621809,0.00001748084],"domain_scores_gemma":[0.9998801,0.00003785591,0.00003922687,0.00001679364,0.0000158534,0.00001018199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003905026,0.00003938315,0.0001056433,0.0003282817,0.00002107614,0.00006182476,0.00002152387,0.0003213953,0.9887488,0.001413652,0.000135845,0.008763583],"study_design_scores_gemma":[0.00003251252,0.001091712,0.001593186,0.0000590041,0.00009321973,0.0003327761,0.00004274705,0.004900775,0.9593098,0.0009825719,0.03153563,0.00002610952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7308843,0.05530614,0.1972619,0.001533137,0.00109446,0.0004693267,0.001023149,0.0006744249,0.01175316],"genre_scores_gemma":[0.882727,0.03188783,0.07405844,0.0007021368,0.0001856965,0.00065296,0.0008283369,0.00009817588,0.008859359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654742,"threshold_uncertainty_score":0.005535662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01830511115094446,"score_gpt":0.2914251903887753,"score_spread":0.2731200792378308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}