{"id":"W2909997018","doi":"10.1093/infdis/jiz015","title":"HIV-Related Arterial Stiffness in Malawian Adults Is Associated With the Proportion of PD-1–Expressing CD8+ T Cells and Reverses With Antiretroviral Therapy","year":2019,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Merck Sharp and Dohme; GlaxoSmithKline; ViiV Healthcare; Gilead Sciences; Wellcome Trust","keywords":"Arterial stiffness; CD38; Medicine; CD8; Pulse wave velocity; Internal medicine; Immunology; Immune system; Young adult; Viral load; Human immunodeficiency virus (HIV); Blood pressure; Biology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002654119,0.00021061,0.0001651125,0.000283004,0.0003092162,0.0003279521,0.0001572108,0.0001702259,0.001212158],"category_scores_gemma":[0.001263392,0.0001876467,0.0001220833,0.0003410555,0.0002385956,0.0002478872,0.0002709789,0.0003401962,0.00009399743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364645,"about_ca_system_score_gemma":0.0002165895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005781631,"about_ca_topic_score_gemma":0.009105055,"domain_scores_codex":[0.9998261,0.00005343196,0.00001399561,0.00002965709,0.00003231547,0.00004458281],"domain_scores_gemma":[0.9994438,0.00009905808,0.0003109144,0.00003015033,0.00005797911,0.00005794567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001551067,0.00001813626,0.9954704,0.00002010965,0.00002884657,0.00007705107,0.0001695068,0.00003598656,0.0009040012,0.00002501191,0.00008868641,0.003007251],"study_design_scores_gemma":[0.000003948349,0.00005244852,0.9991785,0.000009745065,0.00001509057,0.0001840175,0.0001024297,0.0002008231,0.0001062005,0.00001454993,0.0001308886,0.000001433703],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992808,0.0003424877,0.0000752977,0.00004500336,0.000002428107,0.000005219568,0.00009097147,0.000002269266,0.0001555915],"genre_scores_gemma":[0.9996777,0.00009596482,0.00005993522,0.00001150488,0.000004253557,0.000002861098,0.00005157626,4.673964e-7,0.00009572817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005781631,"threshold_uncertainty_score":0.01149595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006123707960768839,"score_gpt":0.2417566521069233,"score_spread":0.2356329441461544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}