{"id":"W2910011258","doi":"10.1038/s41429-018-0137-9","title":"Stable isotope feeding studies reveal a steroid 5(6→7)abeo ring contraction biogenesis for the antibiotic solanioic acid produced by cultures of the fungus Rhizoctonia solani","year":2019,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Plant Disease Resistance and Genetics","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Rhizoctonia solani; Biogenesis; Fungus; Steroid; Natural product; Biology; Stereochemistry; Biosynthesis; Biochemistry; Microbiology; Chemistry; Botany; Hormone; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008080234,0.000166985,0.0003278579,0.0000118734,0.0003924124,0.00006300307,0.0005359152,0.00006841522,0.000007635596],"category_scores_gemma":[0.0001383483,0.00004356964,0.000191578,0.0002254672,0.0001026322,0.000109459,0.00007739515,0.0001669189,0.000002692211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000301367,"about_ca_system_score_gemma":0.00002642438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002512968,"about_ca_topic_score_gemma":0.00008013107,"domain_scores_codex":[0.9986901,0.0001220918,0.0004267299,0.0001320725,0.0003439216,0.0002851051],"domain_scores_gemma":[0.9983682,0.0005029574,0.0006481084,0.0001251342,0.0003096283,0.00004599075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002394086,0.00005803846,0.01276544,0.00006718149,0.0002178408,6.030718e-7,0.0001664007,0.00006901749,0.9825663,0.00001486722,0.002978188,0.0008567445],"study_design_scores_gemma":[0.0003933388,0.0004854453,0.06741164,0.0003279224,0.0004493159,0.00003932145,0.003296709,0.000122627,0.9243587,0.00007184135,0.002872818,0.0001703146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853292,0.01149003,0.000009012062,0.002002639,0.0005098644,0.0004842526,0.000146654,0.000007317919,0.00002099422],"genre_scores_gemma":[0.9950549,0.004197537,0.00004014747,0.0001670854,0.0002796181,7.224173e-8,0.00000342396,0.000002850899,0.000254366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05820756,"threshold_uncertainty_score":0.3018158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199113108327808,"score_gpt":0.2498357681793534,"score_spread":0.2299244573465725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}