{"id":"W2910129845","doi":"10.1038/s41467-018-08163-0","title":"Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; University of Wisconsin Carbone Cancer Center; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; American Heart Association","keywords":"Neuroinflammation; Immune system; Lymphangiogenesis; Antigen; Medicine; Biology; Inflammation; Immunology; Cancer research; Pathology; Cancer; Metastasis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238173,0.0001326749,0.0003084196,0.00009474107,0.0003203373,0.00005766426,0.0004531473,0.0001387568,0.0000257899],"category_scores_gemma":[0.0003638132,0.00009405211,0.0001138566,0.0003594098,0.0001299327,0.00007378512,0.0002594237,0.00004726218,0.00005665817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003641097,"about_ca_system_score_gemma":0.0001833633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007860105,"about_ca_topic_score_gemma":0.0000305694,"domain_scores_codex":[0.9990499,0.0001080652,0.0003448649,0.0001545183,0.0001793592,0.000163281],"domain_scores_gemma":[0.9969976,0.0007021225,0.0001510851,0.001782274,0.0002744113,0.0000925007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001140109,0.000154038,0.01367203,0.0001425692,0.0002323079,0.000002200098,0.001414419,0.000009374869,0.9740953,0.008228432,0.0007910243,0.001144276],"study_design_scores_gemma":[0.00291494,0.0002220732,0.7362761,0.0005449629,0.0005797509,0.00004516818,0.001937217,0.001682866,0.2421367,0.000315923,0.013025,0.0003192988],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788391,0.008595734,0.0000276357,0.007917401,0.0001564192,0.00119816,0.00004843887,0.00004770873,0.003169411],"genre_scores_gemma":[0.9982388,0.0001590492,0.0007128497,0.0005930698,0.00002153883,0.00003482182,0.00005540128,0.00001904199,0.0001654549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7319586,"threshold_uncertainty_score":0.3835334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409218006098191,"score_gpt":0.2717327493865819,"score_spread":0.2576405693256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}