{"id":"W2910159017","doi":"10.1038/s41467-018-07859-7","title":"Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pomegranate: compositions and health benefits","field":"Nursing","cited_by":700,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of General Medical Sciences; Department of Science and Technology, Ministry of Science and Technology, India; National Cancer Institute; National Institutes of Health; Department of Biotechnology, Ministry of Science and Technology, India; National Centre for Biological Sciences; Kentucky IDeA Networks of Biomedical Research Excellence","keywords":"Aryl hydrocarbon receptor; Metabolite; Gut flora; Barrier function; Inflammation; Biology; Cell biology; Function (biology); Microbiome; Biochemistry; Bioinformatics; Immunology; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739796,0.0003224703,0.0002741003,0.0002591765,0.0001905025,0.0002583274,0.0001175147,0.0002775498,0.002121074],"category_scores_gemma":[0.00009772323,0.00007171075,0.0003077305,0.0001076089,0.0001720983,0.000308822,0.0002266331,0.0003565384,0.0002055785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001519607,"about_ca_system_score_gemma":0.0001895923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246421,"about_ca_topic_score_gemma":0.0005481526,"domain_scores_codex":[0.9999241,0.00001763887,0.000005461359,0.00001823941,0.0000160049,0.00001857554],"domain_scores_gemma":[0.9999479,0.000005713459,0.00001756005,0.00000536478,0.00001076158,0.00001274684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005460181,0.00006571269,0.0004181935,0.0002538864,0.00002402015,0.0001305218,0.00002201433,0.00004822811,0.9915739,0.0003017231,0.0001093589,0.006506479],"study_design_scores_gemma":[0.00007087787,0.001373201,0.0131463,0.00004921901,0.00006292842,0.000588882,0.00008681977,0.0005760824,0.9708863,0.0004759729,0.01266995,0.00001354051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641338,0.02152276,0.007298253,0.0008278672,0.0001859939,0.00008018372,0.001011733,0.0001694206,0.004770116],"genre_scores_gemma":[0.9896057,0.004021723,0.00302372,0.0001625992,0.00002497399,0.00003584158,0.0003936681,0.000009452977,0.002722415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121074,"threshold_uncertainty_score":0.007095635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190314405405568,"score_gpt":0.3129825915773966,"score_spread":0.2939511510368398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}