{"id":"W2910164268","doi":"10.1158/1078-0432.ccr-18-0432","title":"CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":672,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Deutsche Krebshilfe","keywords":"Cancer; Antigen; Medicine; Cancer research; Solid tumor; Pathology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002411073,0.0003812112,0.0002772427,0.0001995569,0.0001318044,0.0002420161,0.0002387378,0.0003650309,0.002279643],"category_scores_gemma":[0.00009307357,0.0001133449,0.0002504813,0.0001197693,0.0002315398,0.000253973,0.0001138101,0.0008258408,0.0005529881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002715722,"about_ca_system_score_gemma":0.000528319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401499,"about_ca_topic_score_gemma":0.001838253,"domain_scores_codex":[0.9998981,0.00001603366,0.00000659108,0.00001547682,0.00002706043,0.00003679127],"domain_scores_gemma":[0.9999119,0.00001380173,0.00001988254,0.000007642539,0.00001394891,0.00003279543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006985943,0.0006971121,0.001086892,0.0001875188,0.00003554148,0.0001299934,0.0000526169,0.000687397,0.9826242,0.0003875745,0.0005919692,0.01282052],"study_design_scores_gemma":[0.0002595469,0.009905544,0.003814409,0.00001799394,0.00007550609,0.0005836009,0.00003464317,0.001303988,0.9790908,0.00006437361,0.004844186,0.000005344748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859831,0.004484355,0.004557008,0.0002016379,0.00004321858,0.0001737253,0.00052408,0.0002770745,0.003755838],"genre_scores_gemma":[0.9912225,0.002884805,0.002790626,0.00008317956,0.00001943504,0.00008900474,0.000904164,0.0000374613,0.001968863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279643,"threshold_uncertainty_score":0.007626176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1480627897940606,"score_gpt":0.497207940263481,"score_spread":0.3491451504694204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}