{"id":"W2910296364","doi":"10.3390/biom9010032","title":"Histone Acetylation Promotes Neutrophil Extracellular Trap Formation","year":2019,"lang":"en","type":"article","venue":"Biomolecules","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Mitacs; University of Toronto; Cystic Fibrosis Canada","keywords":"Neutrophil extracellular traps; Histone; Nicotinamide adenine dinucleotide phosphate; Acetylation; Histone deacetylase; NADPH oxidase; Cell biology; Molecular biology; Chemistry; Biology; Biochemistry; Reactive oxygen species; Immunology; Oxidase test; Inflammation; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000137889,0.0002002095,0.0002167038,0.0001415668,0.0001246622,0.0000221516,0.0001734683,0.0001933288,0.0008114169],"category_scores_gemma":[0.0000125328,0.0001756781,0.00009759045,0.0001570845,0.000105642,0.0002509669,0.00004729972,0.0001456385,0.003516081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005281428,"about_ca_system_score_gemma":0.00002494511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002233539,"about_ca_topic_score_gemma":0.000004968134,"domain_scores_codex":[0.9989325,0.0001358496,0.0002687279,0.0003073474,0.00005229472,0.0003032743],"domain_scores_gemma":[0.9994528,0.00002831253,0.0001324751,0.0002941965,0.00006888778,0.00002332846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006093695,0.00007950091,0.00004624132,0.00002650915,0.00003603148,0.000005838018,0.0002008848,0.000002060173,0.9831699,0.01164137,0.00038604,0.004344655],"study_design_scores_gemma":[0.0009324669,0.0002733461,0.0006665554,0.00002833104,0.00002491082,0.00004704735,0.000124435,0.00002272165,0.9737,0.0004878516,0.02346811,0.0002241519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890141,0.00344854,0.004641358,0.0006138036,0.0005292938,0.0004998509,0.00002046124,0.000140048,0.001092499],"genre_scores_gemma":[0.9953654,0.00005081454,0.0003893752,0.0001196581,0.00003176219,0.00002410403,0.0003017465,0.00002453378,0.003692619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02308207,"threshold_uncertainty_score":0.9972598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124968646236381,"score_gpt":0.23771491989054,"score_spread":0.2252180552669019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}