{"id":"W2910296364","doi":"10.3390/biom9010032","title":"Histone Acetylation Promotes Neutrophil Extracellular Trap Formation","year":2019,"lang":"en","type":"article","venue":"Biomolecules","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Mitacs; University of Toronto; Cystic Fibrosis Canada","keywords":"Neutrophil extracellular traps; Histone; Nicotinamide adenine dinucleotide phosphate; Acetylation; Histone deacetylase; NADPH oxidase; Cell biology; Molecular biology; Chemistry; Biology; Biochemistry; Reactive oxygen species; Immunology; Oxidase test; Inflammation; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150078,0.000207624,0.0001617166,0.0001110087,0.0001043505,0.00019702,0.0001025801,0.0001791984,0.002157167],"category_scores_gemma":[0.0001351563,0.00008519558,0.0002118389,0.00006617042,0.00009681203,0.0001198814,0.0002279429,0.0003237395,0.0004666859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877785,"about_ca_system_score_gemma":0.0001299835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004635137,"about_ca_topic_score_gemma":0.0008438287,"domain_scores_codex":[0.9998879,0.00001409344,0.000007470477,0.00002266311,0.00003031646,0.00003753826],"domain_scores_gemma":[0.9999042,0.00001101467,0.00002879976,0.000005785364,0.0000142452,0.00003588757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000201674,0.00002127924,0.0003558482,0.00007076015,0.000007625519,0.00006332558,0.00001249121,0.00004061914,0.9971962,0.00009485294,0.0001028425,0.001832434],"study_design_scores_gemma":[0.00005608548,0.0006651175,0.02130167,0.00001999331,0.00002627751,0.0003765844,0.00003254962,0.0008097911,0.9710334,0.00008997846,0.005579891,0.000008618665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877906,0.004470703,0.003093151,0.0001943225,0.00008534292,0.00005930652,0.000629006,0.0001160332,0.003561505],"genre_scores_gemma":[0.9946241,0.001070053,0.001018112,0.0001054413,0.00002235865,0.00002906997,0.0005859738,0.00001050858,0.002534309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157167,"threshold_uncertainty_score":0.007216513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124968646236381,"score_gpt":0.23771491989054,"score_spread":0.2252180552669019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}