{"id":"W2910300319","doi":"10.3899/jrheum.180045","title":"Variable Clinical Phenotypes and Relation of Interferon Signature with Disease Activity in ADA2 Deficiency","year":2019,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Adenosine deaminase; Interferon; Disease; Biomarker; Immunology; Downregulation and upregulation; Phenotype; Internal medicine; Adenosine deaminase deficiency; Gene; Adenosine; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003466916,0.0003507178,0.0002485387,0.0005072078,0.0002159068,0.0003557417,0.0001295301,0.0003584987,0.001036339],"category_scores_gemma":[0.001166441,0.0001015269,0.0001386378,0.0003321179,0.0002906199,0.0001520497,0.0001856699,0.0002884651,0.0001653622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001324561,"about_ca_system_score_gemma":0.00006337601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001650716,"about_ca_topic_score_gemma":0.0001536706,"domain_scores_codex":[0.9997068,0.000081907,0.00004756431,0.00008415074,0.0000458283,0.00003372872],"domain_scores_gemma":[0.9991809,0.0002736039,0.0003109251,0.00004672617,0.00006974368,0.000118161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001838343,0.00006410201,0.9373175,0.00004408815,0.00004809249,0.002876561,0.0002433991,0.000195019,0.05071154,0.00004367852,0.0001128447,0.006504957],"study_design_scores_gemma":[0.00004132499,0.0007758573,0.9718041,0.00001403471,0.0000510479,0.01984021,0.000191639,0.00053899,0.006248566,0.00008936707,0.0003937465,0.00001114485],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993662,0.0001770791,0.0001742782,0.00001335785,0.000002291132,0.000003334507,0.00006376368,0.000005136278,0.0001944941],"genre_scores_gemma":[0.9996966,0.00002742948,0.0001305648,0.00001099683,0.000005591248,0.000003547437,0.00005778443,0.000001811499,0.00006582457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036339,"threshold_uncertainty_score":0.003466904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007195243969321552,"score_gpt":0.2338165178334329,"score_spread":0.2266212738641113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}