{"id":"W2910300319","doi":"10.3899/jrheum.180045","title":"Variable Clinical Phenotypes and Relation of Interferon Signature with Disease Activity in ADA2 Deficiency","year":2019,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Adenosine deaminase; Interferon; Disease; Biomarker; Immunology; Downregulation and upregulation; Phenotype; Internal medicine; Adenosine deaminase deficiency; Gene; Adenosine; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008361103,0.0000956463,0.000376431,0.00009294591,0.00004977029,0.000002821747,0.0002044281,0.0001478906,0.00007787732],"category_scores_gemma":[0.0001329218,0.00005592117,0.00004344387,0.0001260117,0.0003111996,0.0001239061,0.00004848499,0.0005745848,0.00001122032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001048499,"about_ca_system_score_gemma":0.0001250531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001008457,"about_ca_topic_score_gemma":0.000006817533,"domain_scores_codex":[0.9987699,0.000490391,0.0004477078,0.00009395665,0.00003604396,0.0001619665],"domain_scores_gemma":[0.9987298,0.0005369353,0.000489707,0.0001682721,0.00006883046,0.000006472837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01723601,0.0008214741,0.8880299,0.0001669469,0.0002187213,0.000003627561,0.002230164,0.001148502,0.06909184,0.01294077,0.00005989907,0.008052096],"study_design_scores_gemma":[0.009003201,0.003966935,0.9750144,0.0007174661,0.0002462151,0.001624809,0.002381862,0.0003343641,0.001342064,0.003864645,0.001156978,0.0003469953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837337,0.01487507,0.0004560076,0.0002331848,0.0003593463,0.0001071705,0.000001888765,0.000003929537,0.0002296624],"genre_scores_gemma":[0.9993662,0.0004945424,0.0000332063,0.00002116723,3.745121e-7,5.490418e-7,0.000001617368,0.00000586713,0.00007647584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08698452,"threshold_uncertainty_score":0.2496317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007195243969321552,"score_gpt":0.2338165178334329,"score_spread":0.2266212738641113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}