{"id":"W2910350093","doi":"10.1101/516971","title":"NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Phosphorylation; DNA damage; Carcinogenesis; Suppressor; Tyrosine phosphorylation; Biology; Kinase; Tyrosine; Mutant; Cancer research; Transcriptional regulation; Tyrosine kinase; Cell biology; Mutation; Signal transduction; DNA; Genetics; Transcription factor; Cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006142942,0.0002236497,0.0001065379,0.0001336543,0.0001161269,0.0001864109,0.0001415677,0.0001702213,0.003016012],"category_scores_gemma":[0.00007804321,0.0000799553,0.0001197899,0.00009085549,0.0001546294,0.00009868449,0.000134647,0.0002929399,0.0014328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002471841,"about_ca_system_score_gemma":0.00009525192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000316878,"about_ca_topic_score_gemma":0.0004679421,"domain_scores_codex":[0.999958,0.000004532117,0.000002216934,0.00001133369,0.00001019758,0.00001354568],"domain_scores_gemma":[0.9999632,0.00000613043,0.000008554568,0.000005724291,0.0000034528,0.00001299018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001930285,0.00003027909,0.0005942044,0.00002522076,0.000002999766,0.00009359378,0.000006357898,0.00005851294,0.9967038,0.0001607197,0.0001747187,0.001956536],"study_design_scores_gemma":[0.00002097887,0.0001038354,0.01389555,0.000005409557,0.000003689683,0.0004919207,0.00001773999,0.001032052,0.9797822,0.0001446114,0.004499012,0.000002923457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890884,0.001534215,0.002414134,0.0002485143,0.00006237053,0.00001485968,0.0008023508,0.0001087405,0.005726438],"genre_scores_gemma":[0.9862761,0.0006287668,0.001438433,0.00004412418,0.00001392712,0.00001442165,0.001617796,0.00002467701,0.009941746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003016012,"threshold_uncertainty_score":0.01008964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397400422055029,"score_gpt":0.2225534188195329,"score_spread":0.2085794145989826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}