{"id":"W2910386949","doi":"10.1007/s00467-018-4173-2","title":"A breakthrough in readthrough? Could geneticin lead the way to effective treatment for cystinosis nonsense mutations?","year":2019,"lang":"en","type":"letter","venue":"Pediatric Nephrology","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"","keywords":"Cystinosis; Nonsense; Medicine; Nonsense mutation; Nephrology; Genetics; Missense mutation; Internal medicine; Mutation; Gene; Biology; Cystine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002560721,0.0006394553,0.00135371,0.0005508589,0.002547936,0.00217034,0.001144305,0.0425476,0.005133549],"category_scores_gemma":[0.01986411,0.000385376,0.001137678,0.0003208154,0.002907954,0.004192026,0.001208204,0.02948048,0.002750889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004087559,"about_ca_system_score_gemma":0.003706737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004337223,"about_ca_topic_score_gemma":0.006689149,"domain_scores_codex":[0.9978445,0.0006623533,0.0003047227,0.0002325615,0.0005627687,0.000393146],"domain_scores_gemma":[0.9923208,0.004641706,0.0004311888,0.0002102731,0.0009902328,0.001405767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001936908,0.0001841105,0.002254312,0.0001521177,0.00004717912,0.01698564,0.0002486664,0.0003188351,0.0007340712,0.01706461,0.9322556,0.02956109],"study_design_scores_gemma":[0.0004625781,0.0003507783,0.001810873,0.000716291,0.00006736574,0.01824804,0.00062142,0.001396893,0.0009721752,0.03944546,0.9357789,0.0001292561],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0005100441,0.001655284,0.0001039398,0.9885202,0.007819256,0.000004189361,0.00001617526,0.00001450969,0.001356513],"genre_scores_gemma":[0.01288231,0.003313687,0.0005340212,0.9293804,0.04716744,0.00002302153,0.00002691738,0.00002563395,0.006646588],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.0425476,"threshold_uncertainty_score":0.02965742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03625663266372437,"score_gpt":0.3408624777194465,"score_spread":0.3046058450557221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}