{"id":"W2910402319","doi":"10.1002/ijc.32122","title":"IL‐17R deletion predicts high‐grade colorectal cancer and poor clinical outcomes","year":2019,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Cancer Society Research Institute; IWK Health Centre; Cure Brain Cancer Foundation; Terry Fox Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Microsatellite instability; Colorectal cancer; Biology; Metastasis; Cancer research; Immunohistochemistry; Cancer; Tissue microarray; Microarray analysis techniques; Internal medicine; Oncology; Gene; Gene expression; Medicine; Genetics; Immunology; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003143669,0.0002087955,0.0002202711,0.0006984663,0.0002264871,0.0004273659,0.0002064843,0.000531853,0.004085483],"category_scores_gemma":[0.0009357223,0.0001483419,0.0002908117,0.0005102134,0.0002880962,0.0002329918,0.0003657342,0.0004832024,0.0006482355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303066,"about_ca_system_score_gemma":0.0001738945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008846275,"about_ca_topic_score_gemma":0.001236409,"domain_scores_codex":[0.9998537,0.00003547783,0.00001460208,0.00003497726,0.00002517795,0.00003603385],"domain_scores_gemma":[0.9990922,0.0001428719,0.0003707736,0.00006202024,0.00007146483,0.0002607248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001976882,0.00002048293,0.9967256,0.00001448424,0.00003375335,0.00007799124,0.00001138686,0.00005762011,0.001110402,0.00001618528,0.0001466611,0.001587815],"study_design_scores_gemma":[0.00000635037,0.00006779435,0.9983408,0.000008588225,0.00004199535,0.0004670771,0.00006152863,0.0003315486,0.0002646718,0.00004605294,0.0003604095,0.00000313988],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969661,0.0009678645,0.0001997172,0.0001322821,0.00002012862,0.00001030476,0.0004748746,0.00002309574,0.001205758],"genre_scores_gemma":[0.9988735,0.0002395601,0.000114238,0.00002171526,0.00001813523,0.000006094724,0.0003892816,0.000003430709,0.0003340388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004085483,"threshold_uncertainty_score":0.01366729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02879964626583278,"score_gpt":0.3861500796607714,"score_spread":0.3573504333949387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}