{"id":"W2910406726","doi":"10.1182/blood-2018-99-113516","title":"Somatic PRAME Deletions Are Associated with Decreased Immunogenicity, Apoptosis Resistance and Poor Outcomes in Diffuse Large B-Cell Lymphoma","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Lymphoma; Oncology; Population; Internal medicine; Biology; Immunology; Cancer research; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289431,0.0001814074,0.0002257676,0.0005947159,0.0001541348,0.0003301908,0.0002175197,0.0002581002,0.00125204],"category_scores_gemma":[0.001056425,0.0001514541,0.0001143121,0.0004224706,0.0002193914,0.0001625161,0.00024746,0.0002553526,0.0001904705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307921,"about_ca_system_score_gemma":0.00009259844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004713776,"about_ca_topic_score_gemma":0.0005102151,"domain_scores_codex":[0.9998631,0.00003137256,0.0000152181,0.00004220806,0.0000257621,0.00002220819],"domain_scores_gemma":[0.9992282,0.0001509191,0.0003973065,0.00005520151,0.00005932602,0.0001090693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007086877,0.00003381571,0.9835367,0.00001479229,0.00004755373,0.0005550051,0.0000459379,0.0001094436,0.01190576,0.00001490087,0.00005801133,0.002969255],"study_design_scores_gemma":[0.00001298826,0.0001287853,0.9961057,0.000002126955,0.00002555324,0.002347316,0.00005385417,0.0002461077,0.0009006468,0.00002457449,0.0001497144,0.000002487383],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996719,0.00009466958,0.00006715422,0.000006794539,6.47179e-7,0.000001692259,0.00007365263,0.00000354738,0.0000800115],"genre_scores_gemma":[0.9997904,0.00002440555,0.00003777722,0.000003453863,0.000002087515,0.000001533059,0.00009436224,0.000001080976,0.0000448669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125204,"threshold_uncertainty_score":0.004188418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372126101052848,"score_gpt":0.2649780288094153,"score_spread":0.2512567677988868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}