{"id":"W2910455141","doi":"10.1016/j.dmpk.2018.09.208","title":"Unraveling the metabolic fate of potential therapeutic dimer compounds for Parkinson’s disease","year":2019,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Parkinson's disease; Disease; Medicine; Neuroscience; Chemistry; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005734797,0.0003427441,0.0004690331,0.0002627053,0.000167876,0.001332547,0.0003040472,0.0004321128,0.003046463],"category_scores_gemma":[0.0006141654,0.000301351,0.0003110983,0.0002021601,0.0003292873,0.001280461,0.0002841176,0.001039352,0.0006488158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005927854,"about_ca_system_score_gemma":0.0007736724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000916147,"about_ca_topic_score_gemma":0.002147846,"domain_scores_codex":[0.9998543,0.00005812563,0.000008563055,0.00002799288,0.00002755923,0.0000234433],"domain_scores_gemma":[0.9998261,0.00004691089,0.00005462916,0.00002190106,0.00003456934,0.00001597247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002977792,0.0003084176,0.008880558,0.000874053,0.0002558006,0.0009363722,0.0003646816,0.01048304,0.639564,0.02413186,0.004321829,0.3069016],"study_design_scores_gemma":[0.000447447,0.00639037,0.02670679,0.0003642266,0.000608821,0.008726162,0.001397297,0.06378057,0.630784,0.04713435,0.2134525,0.0002073985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7993737,0.1181709,0.0558252,0.007266305,0.0002423756,0.0001315335,0.001518256,0.0003245168,0.01714716],"genre_scores_gemma":[0.9390872,0.04180131,0.01059178,0.0006562999,0.0001262025,0.00005427865,0.0006219838,0.0001181086,0.006942984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003046463,"threshold_uncertainty_score":0.01019138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0216354847196339,"score_gpt":0.2716738861763285,"score_spread":0.2500384014566946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}