{"id":"W2910486153","doi":"10.3899/jrheum.180455","title":"Gene Expression Pathways across Multiple Tissues in Antineutrophil Cytoplasmic Antibody-associated Vasculitis Reveal Core Pathways of Disease Pathology","year":2019,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Eye Institute; National Institutes of Health; William H. and Mary L. Bauman Foundation; National Heart, Lung, and Blood Institute; Research to Prevent Blindness","keywords":"Medicine; Anti-neutrophil cytoplasmic antibody; Vasculitis; Pathology; Pathogenesis; Gene expression; Immunology; Antibody; Disease; Cytoplasm; Gene; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004843202,0.0004082318,0.0005302277,0.001390413,0.0003622439,0.0006070452,0.0001953265,0.000285204,0.001034673],"category_scores_gemma":[0.0004605789,0.000174819,0.0006164766,0.00102005,0.0003023905,0.0004218523,0.0005119006,0.0003627789,0.0001805034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003608975,"about_ca_system_score_gemma":0.0004331572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009658521,"about_ca_topic_score_gemma":0.001669867,"domain_scores_codex":[0.999495,0.00006764081,0.00002968937,0.0001913245,0.0001205282,0.00009573414],"domain_scores_gemma":[0.9994734,0.0001507405,0.0001925339,0.00003986336,0.00007217076,0.00007122709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00142109,0.0001290359,0.1714853,0.0005831582,0.0004043577,0.0006624219,0.0002804744,0.001854448,0.7918304,0.0003566467,0.0003204601,0.03067213],"study_design_scores_gemma":[0.00002615178,0.0004738405,0.9459313,0.00005905097,0.0002988583,0.001326221,0.0004438789,0.004279702,0.04447703,0.0007940604,0.001866527,0.00002328029],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911947,0.001899606,0.00463203,0.00009090309,0.00001191442,0.00003537507,0.001535429,0.00006173054,0.0005382645],"genre_scores_gemma":[0.9906127,0.0008858623,0.005726868,0.00008882436,0.000009929502,0.00007839305,0.001813418,0.00001494699,0.0007690008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390413,"threshold_uncertainty_score":0.003461361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652465430795344,"score_gpt":0.2706005219061074,"score_spread":0.254075867598154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}