{"id":"W2910585122","doi":"10.1111/imcb.12231","title":"<i>In vitro</i>‐generated <scp>MART</scp>‐1‐specific <scp>CD</scp>8 T cells display a broader T‐cell receptor repertoire than <i>ex vivo</i> naïve and tumor‐infiltrating lymphocytes","year":2019,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"Krembil Foundation; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"T-cell receptor; Biology; Antigen; Repertoire; Cytotoxic T cell; Cell biology; CD8; Ex vivo; In vitro; Major histocompatibility complex; Molecular biology; Antigen-presenting cell; Immunology; T cell; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407047,0.0002636231,0.0001545246,0.0001334746,0.00009867781,0.0003618423,0.0001016646,0.0001840889,0.001478342],"category_scores_gemma":[0.0001091193,0.00008339347,0.0001255658,0.0001032883,0.0001323035,0.0001350051,0.0001271001,0.0005201864,0.0005888703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287745,"about_ca_system_score_gemma":0.0001085256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002509486,"about_ca_topic_score_gemma":0.0004204563,"domain_scores_codex":[0.9998773,0.00002493795,0.0000112058,0.00003318019,0.00002435612,0.00002907035],"domain_scores_gemma":[0.9999137,0.00002592776,0.00001944909,0.00001500915,0.00001037725,0.00001551993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002460264,0.00001290899,0.0001546811,0.000009278412,0.000001404542,0.00001426497,0.000007023874,0.00003514,0.9991002,0.00003491233,0.00002284538,0.0005825676],"study_design_scores_gemma":[0.000004801624,0.00009655306,0.0009844732,0.000001385936,0.000005210607,0.0001113744,0.000008062308,0.0003104478,0.9972581,0.0000201357,0.001198303,0.000001147317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886804,0.0003545705,0.006574499,0.00005799936,0.00002664908,0.00003604262,0.0005129719,0.0001076915,0.003649215],"genre_scores_gemma":[0.9893773,0.0002516171,0.005973716,0.00007249061,0.00002061253,0.00003988648,0.001531465,0.00005458573,0.002678345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001478342,"threshold_uncertainty_score":0.004945576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008317179847681978,"score_gpt":0.2326788479833552,"score_spread":0.2243616681356732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}