{"id":"W2910585122","doi":"10.1111/imcb.12231","title":"<i>In vitro</i>‐generated <scp>MART</scp>‐1‐specific <scp>CD</scp>8 T cells display a broader T‐cell receptor repertoire than <i>ex vivo</i> naïve and tumor‐infiltrating lymphocytes","year":2019,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"Krembil Foundation; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"T-cell receptor; Biology; Antigen; Repertoire; Cytotoxic T cell; Cell biology; CD8; Ex vivo; In vitro; Major histocompatibility complex; Molecular biology; Antigen-presenting cell; Immunology; T cell; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006840759,0.0006536412,0.001196798,0.0003991139,0.0002446474,0.00006523049,0.0003518646,0.0009167728,0.0006554477],"category_scores_gemma":[0.0001486576,0.0005703279,0.0001796803,0.0005297759,0.0009467886,0.0001639102,0.0003005532,0.001097947,0.0004159709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001723699,"about_ca_system_score_gemma":0.0002643772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002824789,"about_ca_topic_score_gemma":0.00002678364,"domain_scores_codex":[0.9955667,0.0006860278,0.0007885568,0.001349895,0.0002052887,0.001403539],"domain_scores_gemma":[0.9967335,0.001705881,0.0002972893,0.0008377974,0.0001675878,0.0002578766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004127499,0.0002898495,0.01138705,0.0001330752,0.0001513533,0.0001226665,0.00144553,0.000003794092,0.9809899,0.00005406439,0.003328433,0.001681541],"study_design_scores_gemma":[0.005103562,0.00110189,0.001210073,0.00005573364,0.00004138256,0.0002687979,0.001416175,0.000150953,0.8222592,0.00006222821,0.1681852,0.00014485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564859,0.02631211,0.000007916699,0.0002097945,0.0009353849,0.0009965897,0.00006505863,0.0001043466,0.01488296],"genre_scores_gemma":[0.9493322,0.008520386,0.0003858141,0.001166268,0.0002878007,0.00008961605,0.0002016836,0.0001060491,0.03991015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1648568,"threshold_uncertainty_score":0.9996748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008317179847681978,"score_gpt":0.2326788479833552,"score_spread":0.2243616681356732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}