{"id":"W2910621645","doi":"10.1073/pnas.1812557116","title":"Multidrug-resistant plasmids repress chromosomally encoded T6SS to enable their dissemination","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Washington University School of Medicine in St. Louis; National Institute of General Medical Sciences; Washington University in St. Louis","keywords":"Plasmid; Type VI secretion system; Biology; Acinetobacter baumannii; Multiple drug resistance; Microbiology; Bacterial conjugation; Bacteria; Acinetobacter; Genetics; Drug resistance; Gene; Virulence; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317059,0.000245166,0.0001823579,0.0001205217,0.0001013281,0.0004113241,0.0001441297,0.0001618409,0.001563368],"category_scores_gemma":[0.0002449464,0.00008243582,0.0001417287,0.00008593204,0.0001616601,0.000241187,0.0003923471,0.0004341792,0.0007470204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002126999,"about_ca_system_score_gemma":0.0001880682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003483553,"about_ca_topic_score_gemma":0.0004696816,"domain_scores_codex":[0.9998434,0.00003417836,0.00001470065,0.0000230379,0.0000549602,0.00002975043],"domain_scores_gemma":[0.9998367,0.00003632589,0.00003919084,0.00003313331,0.000023321,0.00003129547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001593985,0.00001714536,0.0002529168,0.00001326577,0.000001419688,0.00001845224,0.00001296947,0.0000275464,0.9984601,0.0002069086,0.00003560329,0.0009378205],"study_design_scores_gemma":[0.000007852831,0.0001772637,0.003707249,0.0000073875,0.000004618541,0.0002478152,0.0000522322,0.001390725,0.9904826,0.0001559392,0.003760186,0.000006070756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908279,0.000727507,0.005188618,0.0001947021,0.00003568854,0.0000213037,0.0001379127,0.0001389768,0.002727332],"genre_scores_gemma":[0.9954053,0.0002338354,0.002042823,0.00004132599,0.000007927858,0.00001128356,0.0002343144,0.00002918918,0.001993948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563368,"threshold_uncertainty_score":0.00523001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463765001931827,"score_gpt":0.2842416428302805,"score_spread":0.2696039928109622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}