{"id":"W2910636995","doi":"10.3390/cancers11020248","title":"Decoration of Anti-CD38 on Nanoparticles Carrying a STAT3 Inhibitor Can Improve the Therapeutic Efficacy Against Myeloma","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates - Health Solutions","keywords":"CD38; Chemistry; IC50; Cell culture; Cancer research; Pharmacology; Molecular biology; Medicine; In vitro; Biology; Biochemistry; Cell biology; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001110788,0.0001216689,0.000205158,0.00006025538,0.00007044148,0.00001745262,0.00007825375,0.00003988606,0.00004484433],"category_scores_gemma":[0.00005997937,0.00007572315,0.0000724245,0.0001677807,0.00008179322,0.00004371006,0.00001914529,0.000127537,0.00003858784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005818706,"about_ca_system_score_gemma":0.0005971953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003611265,"about_ca_topic_score_gemma":0.00009391916,"domain_scores_codex":[0.9989721,0.0000510097,0.0001775269,0.0002096874,0.0003108822,0.0002787909],"domain_scores_gemma":[0.9992611,0.0001191811,0.00008266939,0.0003300926,0.00009557915,0.000111349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007711325,0.00007778248,0.0372599,0.00009399312,0.0002380846,0.00001923474,0.001077547,0.0004836478,0.8665447,0.00009174139,0.0001522578,0.09319001],"study_design_scores_gemma":[0.006732318,0.001377588,0.162682,0.0002369777,0.00007962079,0.000003340378,0.001198353,0.003760285,0.8228335,0.00002735604,0.0009083519,0.0001603553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997321,0.0002683788,0.000003349971,0.0006355572,0.0002094173,0.0008994603,0.00002738496,0.00002386758,0.0006116029],"genre_scores_gemma":[0.9991983,0.00007386824,0.00002925113,0.0003653666,0.00008651854,0.00004100268,0.00002078928,0.00002031662,0.0001646562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1254221,"threshold_uncertainty_score":0.3087901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02554984418691909,"score_gpt":0.3065976148937081,"score_spread":0.281047770706789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}