{"id":"W2910636995","doi":"10.3390/cancers11020248","title":"Decoration of Anti-CD38 on Nanoparticles Carrying a STAT3 Inhibitor Can Improve the Therapeutic Efficacy Against Myeloma","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates - Health Solutions","keywords":"CD38; Chemistry; IC50; Cell culture; Cancer research; Pharmacology; Molecular biology; Medicine; In vitro; Biology; Biochemistry; Cell biology; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007300518,0.0002635904,0.0001391732,0.00009364841,0.00008470895,0.0001106266,0.000155401,0.0003117595,0.0007165167],"category_scores_gemma":[0.00006560462,0.00009781618,0.0001995871,0.00006800266,0.0001194201,0.0001525765,0.0001189367,0.0002644614,0.0001676281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002681756,"about_ca_system_score_gemma":0.0001080871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007866559,"about_ca_topic_score_gemma":0.001155538,"domain_scores_codex":[0.999931,0.000006399236,0.000003880677,0.00001673409,0.00002429262,0.00001766101],"domain_scores_gemma":[0.9999754,0.000005539771,0.000006996785,0.000002166755,0.000004146893,0.000005672354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004097203,0.00001426024,0.00003210747,0.00002256056,0.000002378862,0.00001703285,0.000005824308,0.0001133545,0.9983557,0.0000296367,0.00003659591,0.00132963],"study_design_scores_gemma":[0.00001061164,0.0002275488,0.0009216245,0.000002663935,0.00001077712,0.00007210774,0.000005740458,0.0017705,0.995743,0.00001873674,0.001213846,0.000002772213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926975,0.001312465,0.004024769,0.00009178122,0.00003056655,0.0000223209,0.00009198153,0.0000808726,0.001647766],"genre_scores_gemma":[0.994089,0.0005733711,0.003583067,0.00005810187,0.000007712873,0.00001801669,0.0001013766,0.00001535999,0.001554103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007866559,"threshold_uncertainty_score":0.002396941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02554984418691909,"score_gpt":0.3065976148937081,"score_spread":0.281047770706789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}