{"id":"W2910645688","doi":"10.7554/elife.39856","title":"Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":311,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Estonian Research Competency Council; SystemsX.ch; Tartu Ülikool; Svenska Forskningsrådet Formas; Medical Research Council; Wellcome; AXA Research Fund; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Wellcome Trust","keywords":"Biology; Genomics; Computational biology; Genetics; Evolutionary biology; Developmental biology; Systems biology; Bioinformatics; Genome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277457,0.00008920918,0.0001867126,0.00001456403,0.00004262862,0.000007136456,0.00006299835,0.00007236046,0.000002591601],"category_scores_gemma":[0.000120335,0.00007866302,0.00003139852,0.00002361333,0.00006498848,0.000001363193,0.0001069935,0.00002934469,0.000001161053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004617272,"about_ca_system_score_gemma":0.00002134492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006818297,"about_ca_topic_score_gemma":0.00005085744,"domain_scores_codex":[0.9994037,0.00003258564,0.0001713801,0.0002079597,0.00005018653,0.0001341671],"domain_scores_gemma":[0.9995845,0.00005084228,0.0001124541,0.0001485398,0.00004501616,0.00005864926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001508268,0.00003171582,0.8758333,0.00002107003,0.00003256237,7.580604e-8,0.00004999926,0.00002364814,0.1228386,0.0001147252,0.0001173298,0.0009218919],"study_design_scores_gemma":[0.0002780459,0.0001581026,0.9883437,0.000008347723,0.0000213224,0.000001936396,0.0001766338,0.0002026307,0.006491988,0.00008954418,0.004118713,0.0001090901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963045,0.00288453,0.0001928437,0.0001336451,0.0001095173,0.0001048349,0.0001445816,0.000004694807,0.0001208549],"genre_scores_gemma":[0.9975847,0.001653699,0.0003874948,0.00009984987,0.000114633,0.000008089225,0.0001082365,0.000008472858,0.00003484818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1163466,"threshold_uncertainty_score":0.3207785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024856125923217,"score_gpt":0.2572841023827137,"score_spread":0.2370355411234815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}