{"id":"W2910660695","doi":"10.1101/515494","title":"Genetic association analyses highlight <i>IL6</i> , <i>ALPL</i> , and <i>NAV1</i> as three new susceptibility genes underlying calcific aortic valve stenosis","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fédération Française de Cardiologie; Institut National de la Santé et de la Recherche Médicale; Conseil Régional des Pays de la Loire; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Agence Nationale de la Recherche; Heart and Stroke Foundation of Canada","keywords":"Genome-wide association study; Biology; Candidate gene; Genetic association; Genetics; Transcriptome; Allele; Gene; Single-nucleotide polymorphism; Expression quantitative trait loci; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005901108,0.0003955493,0.0003499784,0.0007358557,0.000217868,0.0008320668,0.0002247264,0.0003147466,0.006411906],"category_scores_gemma":[0.0009221811,0.0001228604,0.0005991062,0.0008355153,0.0002806709,0.000150319,0.0003719961,0.0006546798,0.000527782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001569478,"about_ca_system_score_gemma":0.0003003992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009197128,"about_ca_topic_score_gemma":0.001376428,"domain_scores_codex":[0.9997781,0.00004478671,0.00001577929,0.00006982637,0.00006404267,0.00002754977],"domain_scores_gemma":[0.999611,0.0001681988,0.0001018698,0.00004145151,0.00002969953,0.00004790937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002799592,0.0002760943,0.4983721,0.0006675992,0.002384372,0.004298438,0.0003937834,0.003864368,0.3617103,0.005142418,0.00916961,0.1109214],"study_design_scores_gemma":[0.000480302,0.0003963797,0.8589861,0.000136065,0.002337486,0.005401373,0.0003752494,0.014081,0.08491793,0.01086849,0.02196634,0.00005324589],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716941,0.004664462,0.01255069,0.002613578,0.0001790873,0.00002328725,0.003140229,0.0005401909,0.004594319],"genre_scores_gemma":[0.9846437,0.00191186,0.007562113,0.0003049979,0.0002274345,0.00001936878,0.001779189,0.00008051661,0.003470784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006411906,"threshold_uncertainty_score":0.02144998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03534250303271091,"score_gpt":0.3141280527316996,"score_spread":0.2787855496989887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}