{"id":"W2910684629","doi":"10.1212/wnl.0000000000006851","title":"Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research on Women's Health; NIH Clinical Center; National Center for Research Resources; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; Netherlands Heart Institute; NIHR Oxford Biomedical Research Centre; Royal Holloway, University of London; National Medical Research Council; National Health and Medical Research Council; Medical Research Council; Leonard M. Miller School of Medicine, University of Miami; National Institutes of Health; College of Medicine, University of Cincinnati; Dementia Centre for Research Collaboration; National Institute on Aging; Universität Greifswald; Stiftung zur Erforschung der Vaskulären Demenz; Centre for Cognitive Ageing and Cognitive Epidemiology; Hjartavernd; Medizinische Universität Graz; Peking Union Medical College; Directorate for Biological Sciences; Göteborgs Universitet; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Neuroscience Research Australia; Leids Universitair Medisch Centrum; Universitat de Barcelona; McKnight Foundation; Pfizer; Centre National de la Recherche Scientifique; Fonds Wetenschappelijk Onderzoek; Vincent Fairfax Family Foundation; National Stroke Foundation; Stichting MS Research; Russian Foundation for Basic Research; Dr. John T. MacDonald Foundation; Universiteit Utrecht; ZonMw; Monash University; Ministero della Salute; Corona-Stiftung; Institut National de la Santé et de la Recherche Médicale; Fondation Leducq; Wellcome Trust; Johns Hopkins University; Agence Nationale de la Recherche; Novartis; North Bristol NHS Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Murdoch University; Leonard M. Miller School of Medicine; Deutsche Forschungsgemeinschaft; Peking Union Medical College Hospital; University of Tasmania; Alzheimer's Association; Hunter Medical Research Institute; Skånes universitetssjukhus; National University of Singapore; Commonwealth Scientific and Industrial Research Organisation; National Heart, Lung, and Blood Institute; Universiteit Leiden; University of Glasgow; University of Oxford; Henry Smith Charity; Newcastle University; UK-India Education and Research Initiative; Centers for Disease Control and Prevention; Austrian Science Fund; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Western Sydney University; Duke-NUS Medical School; Shimane University; Kaiser Permanente Washington Health Research Institute; Menzies Institute for Medical Research; National Center for Global Health and Medicine; Scottish Funding Council; Massachusetts General Hospital; University College London; Centre hospitalier régional universitaire de Lille; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Rush University; Háskóli Íslands; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Medpace; British Heart Foundation; Alzheimer's Research Trust; KU Leuven; University of New South Wales; Singapore Eye Research Institute; University of Pittsburgh; University of Washington; University of Pennsylvania; U.S. Department of Veterans Affairs; Elan; Office of Research and Development; Sahlgrenska Akademin; Stroke Association; Age UK; Université de Bordeaux; Brigham and Women's Hospital; Hersenstichting; Eli Lilly and Company; Genentech; Kaiser Permanente; National University Health System; University of Texas Health Science Center at Houston; BHF Centre of Research Excellence, Oxford; GlaxoSmithKline; University of Edinburgh; University of Miami; Bristol-Myers Squibb; Siemens Healthineers; Lunds Universitet; University of Sydney; Queensland Brain Institute; University of Cincinnati; European Commission; AstraZeneca; School of Medicine, Boston University; Synarc; Karl-Franzens-Universität Graz; Dana Foundation; Institute of Genetics; Ministry of Cultural Affairs; Vlaamse regering; Broad Institute; National Institute of Biomedical Imaging and Bioengineering; Novo Nordisk Fonden; American Heart Association","keywords":"Medicine; Stroke (engine); Population; Genome-wide association study; Internal medicine; Diabetes mellitus; Cardiology; Single-nucleotide polymorphism; Endocrinology; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002675242,0.0001289921,0.0002003946,0.00007316715,0.00005404107,0.000006690784,0.00008446262,0.0002590373,0.00001214608],"category_scores_gemma":[0.0008847206,0.000128026,0.00005368379,0.00005880823,0.00002569208,0.000001608235,0.00004734908,0.0001096783,0.000004277328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006210527,"about_ca_system_score_gemma":0.00004244138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004208592,"about_ca_topic_score_gemma":0.0005164165,"domain_scores_codex":[0.9987918,0.0002347058,0.0002514833,0.000387621,0.00003980379,0.0002945831],"domain_scores_gemma":[0.999127,0.0004456084,0.0001431383,0.0002050408,0.00002982943,0.00004933282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006372308,0.00001707695,0.9901776,0.00000852265,0.00001082957,4.320663e-7,0.0000211722,0.004686125,0.004384816,0.00002009203,0.0002616248,0.0003479542],"study_design_scores_gemma":[0.0008740199,0.0006938918,0.9875888,0.000001437134,0.000008969784,0.000003061655,0.000005312037,0.00654563,0.0001193304,0.000321124,0.003720799,0.0001176267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967774,0.00009026343,0.000684107,0.001862381,0.0001491802,0.0003526222,0.00003085701,0.000009224126,0.00004401162],"genre_scores_gemma":[0.9954242,0.00002412568,0.001747419,0.002486717,0.00006907263,0.00003716403,0.0001423676,0.0000201835,0.00004876659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004265485,"threshold_uncertainty_score":0.5220749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006687054028327913,"score_gpt":0.239843044210545,"score_spread":0.2331559901822171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}