{"id":"W2910684629","doi":"10.1212/wnl.0000000000006851","title":"Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research on Women's Health; NIH Clinical Center; National Center for Research Resources; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; Netherlands Heart Institute; NIHR Oxford Biomedical Research Centre; Royal Holloway, University of London; National Medical Research Council; National Health and Medical Research Council; Medical Research Council; Leonard M. Miller School of Medicine, University of Miami; National Institutes of Health; College of Medicine, University of Cincinnati; Dementia Centre for Research Collaboration; National Institute on Aging; Universität Greifswald; Stiftung zur Erforschung der Vaskulären Demenz; Centre for Cognitive Ageing and Cognitive Epidemiology; Hjartavernd; Medizinische Universität Graz; Peking Union Medical College; Directorate for Biological Sciences; Göteborgs Universitet; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Neuroscience Research Australia; Leids Universitair Medisch Centrum; Universitat de Barcelona; McKnight Foundation; Pfizer; Centre National de la Recherche Scientifique; Fonds Wetenschappelijk Onderzoek; Vincent Fairfax Family Foundation; National Stroke Foundation; Stichting MS Research; Russian Foundation for Basic Research; Dr. John T. MacDonald Foundation; Universiteit Utrecht; ZonMw; Monash University; Ministero della Salute; Corona-Stiftung; Institut National de la Santé et de la Recherche Médicale; Fondation Leducq; Wellcome Trust; Johns Hopkins University; Agence Nationale de la Recherche; Novartis; North Bristol NHS Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Murdoch University; Leonard M. Miller School of Medicine; Deutsche Forschungsgemeinschaft; Peking Union Medical College Hospital; University of Tasmania; Alzheimer's Association; Hunter Medical Research Institute; Skånes universitetssjukhus; National University of Singapore; Commonwealth Scientific and Industrial Research Organisation; National Heart, Lung, and Blood Institute; Universiteit Leiden; University of Glasgow; University of Oxford; Henry Smith Charity; Newcastle University; UK-India Education and Research Initiative; Centers for Disease Control and Prevention; Austrian Science Fund; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Western Sydney University; Duke-NUS Medical School; Shimane University; Kaiser Permanente Washington Health Research Institute; Menzies Institute for Medical Research; National Center for Global Health and Medicine; Scottish Funding Council; Massachusetts General Hospital; University College London; Centre hospitalier régional universitaire de Lille; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Rush University; Háskóli Íslands; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Medpace; British Heart Foundation; Alzheimer's Research Trust; KU Leuven; University of New South Wales; Singapore Eye Research Institute; University of Pittsburgh; University of Washington; University of Pennsylvania; U.S. Department of Veterans Affairs; Elan; Office of Research and Development; Sahlgrenska Akademin; Stroke Association; Age UK; Université de Bordeaux; Brigham and Women's Hospital; Hersenstichting; Eli Lilly and Company; Genentech; Kaiser Permanente; National University Health System; University of Texas Health Science Center at Houston; BHF Centre of Research Excellence, Oxford; GlaxoSmithKline; University of Edinburgh; University of Miami; Bristol-Myers Squibb; Siemens Healthineers; Lunds Universitet; University of Sydney; Queensland Brain Institute; University of Cincinnati; European Commission; AstraZeneca; School of Medicine, Boston University; Synarc; Karl-Franzens-Universität Graz; Dana Foundation; Institute of Genetics; Ministry of Cultural Affairs; Vlaamse regering; Broad Institute; National Institute of Biomedical Imaging and Bioengineering; Novo Nordisk Fonden; American Heart Association","keywords":"Medicine; Stroke (engine); Population; Genome-wide association study; Internal medicine; Diabetes mellitus; Cardiology; Single-nucleotide polymorphism; Endocrinology; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003159699,0.001062779,0.001034075,0.001135002,0.0003786327,0.001292428,0.0006349037,0.0008351066,0.001478261],"category_scores_gemma":[0.005609124,0.0005050763,0.003748415,0.001891744,0.0003547413,0.0004547745,0.0007577318,0.0009527634,0.0001347045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427771,"about_ca_system_score_gemma":0.0004149865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003039873,"about_ca_topic_score_gemma":0.004159841,"domain_scores_codex":[0.9984335,0.0006800972,0.0001492518,0.0004869631,0.000144362,0.0001058191],"domain_scores_gemma":[0.9977991,0.0009087584,0.0005658627,0.0004388955,0.0001390691,0.0001483999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001318922,0.0000579515,0.9574921,0.0002297883,0.03396144,0.0002136098,0.00006029986,0.0005227835,0.001578382,0.0001487894,0.0002805099,0.004135452],"study_design_scores_gemma":[0.0001725131,0.0003634797,0.9714399,0.0001043125,0.02412966,0.0004828577,0.0001145697,0.00141052,0.0005351049,0.0005017245,0.0007300442,0.00001536856],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742373,0.01941472,0.00345847,0.0005596187,0.0001398472,0.00003116716,0.001312811,0.00007379746,0.0007722555],"genre_scores_gemma":[0.9974413,0.001301114,0.0006457703,0.00008399088,0.00006005122,0.0000165899,0.0003212069,0.000009340662,0.000120706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003159699,"threshold_uncertainty_score":0.01671028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006687054028327913,"score_gpt":0.239843044210545,"score_spread":0.2331559901822171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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