{"id":"W2910769610","doi":"10.1016/j.bcp.2019.01.005","title":"SARM: From immune regulator to cell executioner","year":2019,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland","keywords":"TRIF; Biology; Cell biology; Innate immune system; Signal transducing adaptor protein; Regulator; Axon; NAD+ kinase; Immune system; Toll-like receptor; Signal transduction; Gene; Biochemistry; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000105,0.0005373972,0.001202195,0.0002349799,0.000102569,0.00005330024,0.0008122341,0.000440851,0.002243534],"category_scores_gemma":[0.0001327707,0.0004861474,0.0004303817,0.0004774681,0.00007227656,0.00007081761,0.0003707875,0.0005773336,0.008612977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001121489,"about_ca_system_score_gemma":0.0001984019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001970324,"about_ca_topic_score_gemma":2.096304e-8,"domain_scores_codex":[0.9965799,0.0005084957,0.0008459608,0.001270924,0.0003284648,0.0004662427],"domain_scores_gemma":[0.9982613,0.0004521661,0.0003749434,0.0005524022,0.0000416779,0.0003175651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001671367,0.00007020684,6.18018e-9,0.0005521731,0.000007663212,0.00001989181,0.000008575164,0.00000156174,0.8513049,0.0001562101,0.1412411,0.006621043],"study_design_scores_gemma":[0.0001956997,0.00002677815,4.024873e-8,0.00008978078,0.0001433652,0.0000107484,3.294285e-7,0.00001224196,0.4926211,0.0000163582,0.5066379,0.0002456266],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002613182,0.9879304,0.0001455007,0.0003641243,0.005418539,0.002031272,0.0003418432,0.0003020569,0.0008531198],"genre_scores_gemma":[0.0004212743,0.9887434,0.0002287194,0.004429105,0.0009294942,0.0002229565,0.0001458279,0.0001170657,0.00476215],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3653969,"threshold_uncertainty_score":0.999759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09844813468393335,"score_gpt":0.3661427294046126,"score_spread":0.2676945947206792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}