{"id":"W2910769610","doi":"10.1016/j.bcp.2019.01.005","title":"SARM: From immune regulator to cell executioner","year":2019,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland","keywords":"TRIF; Biology; Cell biology; Innate immune system; Signal transducing adaptor protein; Regulator; Axon; NAD+ kinase; Immune system; Toll-like receptor; Signal transduction; Gene; Biochemistry; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005028067,0.001435907,0.001579898,0.001655756,0.0003024703,0.001432869,0.001258319,0.001467043,0.003308288],"category_scores_gemma":[0.000582965,0.0003137181,0.0004101596,0.001822117,0.0009920421,0.00157768,0.001021538,0.004077553,0.00347173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007199095,"about_ca_system_score_gemma":0.001072312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006751759,"about_ca_topic_score_gemma":0.00132134,"domain_scores_codex":[0.9998747,0.00001891819,0.00001828027,0.0000281676,0.0000412276,0.00001867501],"domain_scores_gemma":[0.9998386,0.0000563189,0.00002848001,0.000008273578,0.00003907157,0.00002920933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002013466,0.0001090063,0.0001381037,0.01027812,0.0000787299,0.0003010101,0.00004790915,0.0006406562,0.004837779,0.007871199,0.05765627,0.9178399],"study_design_scores_gemma":[0.00003715283,0.00009765426,0.0003923462,0.001155076,0.0000737728,0.0008196454,0.00003228651,0.0001123361,0.0009783389,0.004072383,0.9922078,0.00002117264],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001143745,0.9971831,0.0003140274,0.0004335061,0.0005574662,0.000005761988,0.00003737632,0.00001855878,0.001335833],"genre_scores_gemma":[0.0009058481,0.9960555,0.0003500021,0.0004932548,0.0006067467,0.00001070512,0.0000719978,0.00000351568,0.00150243],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003308288,"threshold_uncertainty_score":0.01106733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09844813468393335,"score_gpt":0.3661427294046126,"score_spread":0.2676945947206792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}