{"id":"W2910881983","doi":"10.1016/j.yrtph.2019.01.021","title":"Chemical carcinogenicity revisited 1: A unified theory of carcinogenicity based on contemporary knowledge","year":2019,"lang":"en","type":"review","venue":"Regulatory Toxicology and Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; U.S. Food and Drug Administration; National Institutes of Health; Swiss Centre for Applied Human Toxicology; European Food Safety Authority; World Health Organization; U.S. Environmental Protection Agency","keywords":"Carcinogen; Carcinogenesis; Cell growth; Cancer; Cancer cell; DNA damage; Cancer research; Biology; Cell; DNA; Toxicology; Computational biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001074032,0.0008270798,0.002518167,0.0003360391,0.0001189114,0.00001057632,0.000555145,0.001825941,0.0002280182],"category_scores_gemma":[0.00005999359,0.0007573332,0.0009022798,0.0002742167,0.0007176262,0.000005084681,0.0004298721,0.0007392598,0.00002143553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001232086,"about_ca_system_score_gemma":0.001562069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003662368,"about_ca_topic_score_gemma":0.000003400673,"domain_scores_codex":[0.9950249,0.001912563,0.001012819,0.0012744,0.0001905308,0.0005848551],"domain_scores_gemma":[0.997515,0.0004698741,0.0006928215,0.0008800421,0.0001689753,0.0002732494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004735091,0.00363248,0.001054684,0.05357561,0.006040053,0.0001442448,0.0001795978,0.00007949084,0.6482844,0.003968233,0.03816875,0.2401373],"study_design_scores_gemma":[0.002805145,0.001481422,0.0002748015,0.0009078934,0.002381196,0.0001147866,0.00001901132,0.00009442218,0.07113843,0.00004645286,0.919614,0.001122509],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04779634,0.947715,0.0000614919,0.00002501731,0.0008217696,0.001818898,0.0004518873,0.00002786467,0.001281716],"genre_scores_gemma":[0.3795935,0.6173962,0.00006286812,0.0007371195,0.0005113414,0.0001896646,0.0007502064,0.0001111995,0.0006479298],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8814452,"threshold_uncertainty_score":0.9994878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05900963407906776,"score_gpt":0.3491559973356383,"score_spread":0.2901463632565706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}