{"id":"W2910882807","doi":"10.1182/blood-2018-99-112010","title":"Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 As a Therapeutic Target for Restoring MHC Expression in Diffuse Large B-Cell Lymphoma","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"Biology; Major histocompatibility complex; Diffuse large B-cell lymphoma; Cancer research; MHC class I; Immune system; Lymphoma; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009069042,0.0001234736,0.0001769033,0.0001946162,0.00006991956,0.0001494467,0.0001120726,0.0001587364,0.0005435551],"category_scores_gemma":[0.0001125516,0.00007397473,0.0000651115,0.0001430168,0.0001323308,0.00005321567,0.00007050925,0.000150241,0.0001053461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176859,"about_ca_system_score_gemma":0.0001433148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010915,"about_ca_topic_score_gemma":0.002322805,"domain_scores_codex":[0.9999516,0.000006449129,0.000002922393,0.000009664075,0.00001828439,0.00001102948],"domain_scores_gemma":[0.9999639,0.000007221268,0.000009912469,0.000003826382,0.000005497419,0.000009731643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005536797,0.00003910514,0.01687266,0.00003655492,0.00001794027,0.0003826151,0.00001775996,0.0001599837,0.9757012,0.00005494812,0.00007209471,0.00609152],"study_design_scores_gemma":[0.0001854823,0.001223007,0.4675795,0.000008289151,0.0001208563,0.004965193,0.0001139184,0.003666481,0.5188162,0.000144141,0.003170467,0.000006553876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998992,0.0002896852,0.0003564073,0.00002737723,0.000001392212,0.000006101553,0.00009010716,0.000009414371,0.0002274648],"genre_scores_gemma":[0.9991965,0.0001158215,0.0002786031,0.00001385807,0.000001685064,0.000005424291,0.0001558635,0.00000245924,0.0002297355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010915,"threshold_uncertainty_score":0.002010047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007902801343226767,"score_gpt":0.223671287893918,"score_spread":0.2157684865506912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}