{"id":"W2910949845","doi":"10.1101/519967","title":"Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Ellison Medical Foundation; Directorate for Biological Sciences; National Institutes of Health; Centre for Cognitive Ageing and Cognitive Epidemiology; Academy of Finland; University of Edinburgh; Universitetet i Bergen; Samfundet Folkhälsan; Bergens Forskningsstiftelse; Signe ja Ane Gyllenbergin Säätiö; Medical Research Council; Emil Aaltosen Säätiö; Helse Vest; Novo Nordisk; Norges Forskningsråd; Canadian Institutes of Health Research; Science Foundation Ireland; National Science Foundation; Centre for Addiction and Mental Health Foundation; Finska Läkaresällskapet; Age UK; Helsingin Yliopisto; Folkhälsanin Tutkimussäätiö","keywords":"Schizophrenia (object-oriented programming); Cognition; Genome-wide association study; Psychology; Genetic association; Neuroscience; Biology; Genetics; Psychiatry; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01023095,0.001304229,0.002795432,0.002735737,0.0009265653,0.002412382,0.001157543,0.0009861726,0.002887783],"category_scores_gemma":[0.01590131,0.0007262165,0.01368408,0.003754335,0.0006605375,0.0006591213,0.001682404,0.001692684,0.0002302107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005758692,"about_ca_system_score_gemma":0.001207504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005447092,"about_ca_topic_score_gemma":0.00893627,"domain_scores_codex":[0.9931405,0.003988494,0.0007060997,0.001295237,0.0005596992,0.0003099158],"domain_scores_gemma":[0.9878191,0.007910219,0.001218348,0.00207436,0.0006002079,0.0003777926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00522112,0.00006121345,0.4313881,0.005602199,0.5258704,0.0007986968,0.0001741027,0.004335707,0.007182878,0.001530396,0.002052752,0.01578236],"study_design_scores_gemma":[0.0007137695,0.0006960173,0.3574751,0.001350516,0.6160859,0.0008861976,0.000229846,0.01044418,0.002780945,0.004761862,0.004505041,0.00007060334],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7267148,0.2199442,0.03712345,0.002804887,0.0007484267,0.0001671057,0.008758291,0.0006446028,0.00309419],"genre_scores_gemma":[0.9882449,0.006665362,0.003292641,0.0002462732,0.0001006998,0.00007170755,0.001052954,0.00006730894,0.0002580806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01023095,"threshold_uncertainty_score":0.05410707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592100233014124,"score_gpt":0.2240478725946718,"score_spread":0.2081268702645306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}