{"id":"W2910949845","doi":"10.1101/519967","title":"Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Ellison Medical Foundation; Directorate for Biological Sciences; National Institutes of Health; Centre for Cognitive Ageing and Cognitive Epidemiology; Academy of Finland; University of Edinburgh; Universitetet i Bergen; Samfundet Folkhälsan; Bergens Forskningsstiftelse; Signe ja Ane Gyllenbergin Säätiö; Medical Research Council; Emil Aaltosen Säätiö; Helse Vest; Novo Nordisk; Norges Forskningsråd; Canadian Institutes of Health Research; Science Foundation Ireland; National Science Foundation; Centre for Addiction and Mental Health Foundation; Finska Läkaresällskapet; Age UK; Helsingin Yliopisto; Folkhälsanin Tutkimussäätiö","keywords":"Schizophrenia (object-oriented programming); Cognition; Genome-wide association study; Psychology; Genetic association; Neuroscience; Biology; Genetics; Psychiatry; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002192302,0.00030615,0.0009712821,0.0002445184,0.00005534711,0.0000278252,0.0001844351,0.000364295,0.00001543258],"category_scores_gemma":[0.0002277383,0.0002935411,0.000279782,0.0002041211,0.0001403458,0.000005141466,0.0003356742,0.0001552379,0.00000119854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001288866,"about_ca_system_score_gemma":0.0003205023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005077729,"about_ca_topic_score_gemma":0.00001646143,"domain_scores_codex":[0.9982714,0.0001770641,0.0005804063,0.0006363764,0.0001328091,0.000201909],"domain_scores_gemma":[0.9980478,0.0000449684,0.0006484086,0.0005286642,0.000636706,0.00009349667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004230004,0.0002043537,0.3202879,0.0002859081,0.04645506,4.717427e-7,0.00002571623,0.00008074143,0.6322347,0.0003090104,0.0000688624,0.000004950744],"study_design_scores_gemma":[0.0002461594,0.0000899436,0.9345002,0.00001829693,0.02408404,1.627324e-8,0.000009835823,0.000124225,0.04061835,0.000009862749,0.00001848906,0.0002806306],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932695,0.005350602,0.000427743,0.00005582122,0.0001138086,0.0002842498,0.0004845958,0.00001094631,0.000002705008],"genre_scores_gemma":[0.9954125,0.001007561,0.003336911,0.00007938882,0.00004091621,0.00007425169,0.00001341899,0.00003117552,0.000003874055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6142122,"threshold_uncertainty_score":0.9999517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592100233014124,"score_gpt":0.2240478725946718,"score_spread":0.2081268702645306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}