{"id":"W2910985072","doi":"10.1021/jacs.8b10207","title":"CRIF1–CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Mitacs; National Natural Science Foundation of China","keywords":"Chemistry; Cyclin-dependent kinase 2; Cyclin-dependent kinase; Cell cycle; Kinase; Cancer research; Cell growth; Cell; Small molecule; Radiosensitivity; Cell biology; Cell cycle checkpoint; Biochemistry; Biology; Radiation therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711817,0.000684655,0.0006320528,0.0003961216,0.0001699139,0.0005190839,0.00044085,0.0003221062,0.001724478],"category_scores_gemma":[0.0001348128,0.0002116092,0.0004167012,0.0002607082,0.0001508482,0.0003249441,0.0003666018,0.001003925,0.0004371838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003360584,"about_ca_system_score_gemma":0.0002365101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005156121,"about_ca_topic_score_gemma":0.00126827,"domain_scores_codex":[0.999893,0.00001555907,0.000006185518,0.00003162348,0.00002420287,0.00002942703],"domain_scores_gemma":[0.9999652,0.000005407585,0.000008246628,0.000003907628,0.000006268046,0.00001093933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003912034,0.0002461979,0.0002689294,0.0004612343,0.00006446038,0.0002705268,0.00004634979,0.002063456,0.9595085,0.001397372,0.001053345,0.03422838],"study_design_scores_gemma":[0.0002306564,0.001729608,0.001446668,0.0000452511,0.0001635362,0.0009214254,0.00003356247,0.005037644,0.9552621,0.0003952395,0.03469031,0.00004396944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.868964,0.04577439,0.05712369,0.001135286,0.0003652276,0.0006386117,0.002105951,0.001192124,0.02270069],"genre_scores_gemma":[0.9584839,0.01678783,0.01614264,0.00041298,0.00005969892,0.0002198222,0.00130137,0.00007187082,0.006519911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001724478,"threshold_uncertainty_score":0.005768955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309964143614363,"score_gpt":0.2810971216367689,"score_spread":0.2679974802006252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}