{"id":"W2910985072","doi":"10.1021/jacs.8b10207","title":"CRIF1–CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Mitacs; National Natural Science Foundation of China","keywords":"Chemistry; Cyclin-dependent kinase 2; Cyclin-dependent kinase; Cell cycle; Kinase; Cancer research; Cell growth; Cell; Small molecule; Radiosensitivity; Cell biology; Cell cycle checkpoint; Biochemistry; Biology; Radiation therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002728277,0.0001259828,0.0004469165,0.00001746059,0.00002209688,0.000008459192,0.0001440589,0.00007990023,0.00001410097],"category_scores_gemma":[0.00007363053,0.00009059077,0.0006200908,0.0002439651,0.0001817213,0.00008467362,0.00004908054,0.0003977304,0.000001307493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002830063,"about_ca_system_score_gemma":0.0001328703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003573515,"about_ca_topic_score_gemma":7.865703e-7,"domain_scores_codex":[0.9988857,0.00005508586,0.000408315,0.0001475554,0.0003332968,0.0001700278],"domain_scores_gemma":[0.9984564,0.00008169518,0.0008460965,0.0002634967,0.0002407575,0.0001115511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003878597,0.0001939495,0.001260895,0.00005295342,0.0001073594,5.891686e-7,0.0002990158,0.001287111,0.9930313,0.00000131787,0.002313108,0.001064568],"study_design_scores_gemma":[0.001635014,0.000708827,0.003095152,0.0001202621,0.0001517864,0.00006292891,0.0006049842,0.007118721,0.9860935,0.00004709501,0.0002658915,0.00009586148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966153,0.00005651843,0.002180973,0.000567724,0.0001812207,0.0002807531,0.000007012568,0.000009557972,0.0001009651],"genre_scores_gemma":[0.996111,0.00002004255,0.003309588,0.0002826032,0.0001939642,0.000001277648,0.000003621841,0.00002487423,0.00005303904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006937797,"threshold_uncertainty_score":0.3694185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309964143614363,"score_gpt":0.2810971216367689,"score_spread":0.2679974802006252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}