{"id":"W2911017829","doi":"10.1136/bmjopen-2018-023765","title":"Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial","year":2019,"lang":"en","type":"article","venue":"BMJ Open","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Efficacy and Mechanism Evaluation Programme; Medical Research Council; National Institute for Health and Care Research; Wellcome Trust","keywords":"Medicine; Clinical trial; Colectomy; Ulcerative colitis; Placebo; Internal medicine; Infliximab; Randomized controlled trial; Clinical endpoint; Incidence (geometry); Anakinra; Disease; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02518914,0.006230305,0.009890556,0.001519301,0.0034712,0.005434879,0.003700471,0.008390473,0.1703674],"category_scores_gemma":[0.03810538,0.002936215,0.005884247,0.002696928,0.003460753,0.003969079,0.00195351,0.01015338,0.0334454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004057243,"about_ca_system_score_gemma":0.01106321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142771,"about_ca_topic_score_gemma":0.003744035,"domain_scores_codex":[0.9766886,0.01382653,0.002718269,0.00278265,0.00216302,0.001820963],"domain_scores_gemma":[0.9854587,0.003384569,0.003081556,0.00261077,0.003118808,0.002345529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8104051,0.003797785,0.0007974624,0.04204847,0.003023358,0.0003827516,0.0003853721,0.00129369,0.002118146,0.01070967,0.0879954,0.03704283],"study_design_scores_gemma":[0.8799139,0.009470806,0.001262174,0.007022151,0.001146724,0.000139333,0.0001097416,0.001396738,0.0005592147,0.005845312,0.09301449,0.0001195161],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001485153,0.001144566,0.002909278,0.0008045061,0.001991282,0.981276,0.006659271,0.0002606988,0.003469189],"genre_scores_gemma":[0.002927105,0.0003660447,0.00254265,0.000649482,0.000250315,0.9903736,0.001064861,0.00002972075,0.001796247],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1703674,"threshold_uncertainty_score":0.5699357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04509148158752204,"score_gpt":0.3993428257761475,"score_spread":0.3542513441886255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}