{"id":"W2911065823","doi":"10.1182/blood-2018-99-112177","title":"Safety of Caplacizumab for the Treatment of Patients with Acquired Thrombotic Thrombocytopenic Purpura - Results Normalized to Time of Exposure in a Double-Blind, Placebo-Controlled, Phase 3 Hercules Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Thrombotic microangiopathy; Medicine; ADAMTS13; Von Willebrand factor; Placebo; Internal medicine; Gastroenterology; Thrombotic thrombocytopenic purpura; Platelet; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003573308,0.0002560696,0.001070094,0.0001428348,0.0001017766,0.000006257852,0.0003419196,0.00008228545,0.0002448363],"category_scores_gemma":[0.00006656506,0.0001519716,0.0001595724,0.0002184463,0.0002012945,0.00006147651,0.00006148895,0.00002968247,0.00002043501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004877905,"about_ca_system_score_gemma":0.0001116284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002679976,"about_ca_topic_score_gemma":0.0007259002,"domain_scores_codex":[0.99792,0.0002924588,0.001048068,0.0003336262,0.0001083942,0.0002974655],"domain_scores_gemma":[0.997884,0.0005716011,0.0005459319,0.0006752908,0.000300717,0.00002239794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8824884,0.03751083,0.03743707,0.00008781953,0.004988428,0.000002438338,0.0113377,0.00005256723,0.02544569,0.00004037763,0.0001708472,0.000437866],"study_design_scores_gemma":[0.8638285,0.03296269,0.04863129,0.0001363066,0.0016748,0.00000249562,0.00168669,0.000005184583,0.05066616,0.000004768357,0.0001932915,0.0002078219],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877433,0.0004989382,0.00001448224,0.00003035786,0.0001061868,0.01054115,0.0009468246,0.00001414241,0.0001046539],"genre_scores_gemma":[0.9987923,0.000008636592,0.00005859607,0.000006332328,0.00001721266,0.0007282216,0.0001909481,0.00001924251,0.0001785013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02522047,"threshold_uncertainty_score":0.6197224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02789615973265892,"score_gpt":0.2980607483440291,"score_spread":0.2701645886113702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}