{"id":"W2911094905","doi":"10.1182/blood-2018-99-113582","title":"Radius: A Phase 2 Randomized Trial Investigating Standard of Care ± Midostaurin after Allogeneic Stem Cell Transplant in FLT3-ITD-Mutated AML","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Midostaurin; Internal medicine; Clinical endpoint; Maintenance therapy; Surgery; Transplantation; Oncology; Chemotherapy regimen; Randomized controlled trial; Myeloid leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001705887,0.00145081,0.002322799,0.0003884692,0.0003633634,0.001024691,0.0009951869,0.001280819,0.006792785],"category_scores_gemma":[0.001584798,0.0005041115,0.001675132,0.0003458642,0.0008617974,0.0009187344,0.0005557842,0.002466409,0.001021861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008403771,"about_ca_system_score_gemma":0.001225588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006843725,"about_ca_topic_score_gemma":0.002520207,"domain_scores_codex":[0.9990984,0.0005116126,0.00006453075,0.0001707297,0.00006798843,0.00008672778],"domain_scores_gemma":[0.9992373,0.0001456213,0.0002398781,0.00005732174,0.00005137362,0.0002685726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9725003,0.005150616,0.0005941626,0.001049051,0.0009919321,0.00004196003,0.00004403777,0.0003075492,0.003443327,0.0001850431,0.001017925,0.01467407],"study_design_scores_gemma":[0.9419425,0.05509202,0.0009238935,0.00004005672,0.0005851177,0.0000419764,0.00001872621,0.0002315672,0.0003334976,0.0001117284,0.0006674242,0.00001151883],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784049,0.007470577,0.0007258434,0.0009714164,0.0005410481,0.007734219,0.001387365,0.0002399483,0.002524645],"genre_scores_gemma":[0.9785327,0.003414126,0.0028,0.001657852,0.0004244034,0.008618863,0.001396035,0.00002510097,0.003130887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006792785,"threshold_uncertainty_score":0.02272415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01583776255456517,"score_gpt":0.2942481510434279,"score_spread":0.2784103884888628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}