{"id":"W2911100812","doi":"10.1158/1078-0432.ccr-18-3102","title":"Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; Susan G. Komen; National Center for Research Resources; U.S. Department of Defense","keywords":"Breast cancer; CD8; Cancer; Medicine; Immunology; Human breast; Cytotoxic T cell; Virology; Biology; Cancer research; Immune system; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001143846,0.0007746595,0.0005478744,0.0002834555,0.0001672737,0.0005264226,0.0004047526,0.0007760167,0.004185661],"category_scores_gemma":[0.0002672641,0.0002074803,0.0004062664,0.0001489461,0.0004454173,0.0005310542,0.0002142159,0.002136566,0.0005959592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000449102,"about_ca_system_score_gemma":0.0005583863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003520316,"about_ca_topic_score_gemma":0.0004270904,"domain_scores_codex":[0.9997482,0.00009490895,0.00001486132,0.00003933452,0.00002565406,0.00007705065],"domain_scores_gemma":[0.9998585,0.00003094018,0.00002237821,0.00002401017,0.00001946164,0.00004471345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01197022,0.01495324,0.001154879,0.0005423754,0.0001273049,0.0001944557,0.0001700549,0.0009354089,0.9318822,0.0009501652,0.002820225,0.03429952],"study_design_scores_gemma":[0.03054324,0.2642727,0.01869146,0.0002580954,0.0005088511,0.0016158,0.0002966251,0.005031917,0.6420411,0.001356604,0.03533993,0.00004364519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877498,0.004119331,0.002552719,0.001221768,0.0001946075,0.0005593864,0.0007999627,0.0002482085,0.002554212],"genre_scores_gemma":[0.9899187,0.002584221,0.002101379,0.0004564699,0.0001343979,0.0005295563,0.001064933,0.00002811941,0.003182159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004185661,"threshold_uncertainty_score":0.01400238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1484707066319882,"score_gpt":0.4882624401638564,"score_spread":0.3397917335318683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}