{"id":"W2911134236","doi":"10.1182/blood-2018-99-117229","title":"Targeting Oncogenic Polyamines in Refractory Pediatric Leukemias Using the Anti-Protozoan Drug Α-Difluoromethylornithine (DFMO) in Combination with GC7 and Aurothioglucose","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Ornithine decarboxylase; Spermidine; Polyamine; Biology; Cancer research; Pharmacology; Cell growth; Population; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583636,0.0002988076,0.0005788385,0.0002349991,0.0001591999,0.0002219829,0.0002555648,0.0002488797,0.0007764251],"category_scores_gemma":[0.00009889334,0.00007532912,0.0002296472,0.0002274542,0.0001586488,0.0001770457,0.0001723032,0.0004152004,0.0001494241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002974677,"about_ca_system_score_gemma":0.0003343863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120334,"about_ca_topic_score_gemma":0.002564414,"domain_scores_codex":[0.9999273,0.00001436237,0.000008472164,0.00001196777,0.00001570758,0.00002220089],"domain_scores_gemma":[0.9999293,0.00001253264,0.00001839669,0.000006301336,0.000007488105,0.00002595342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007647285,0.001728866,0.004306353,0.0006617819,0.0001504244,0.0009614978,0.000227202,0.001221641,0.8981394,0.0002488707,0.0007089634,0.0839977],"study_design_scores_gemma":[0.002329544,0.06267224,0.03533051,0.00009953805,0.0005290756,0.005291253,0.0002571208,0.003395774,0.8595781,0.0001239999,0.03036021,0.00003262316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918633,0.00652512,0.0004393329,0.00009109914,0.00003437955,0.00009273667,0.0001560926,0.00003634517,0.0007615329],"genre_scores_gemma":[0.9932858,0.004461106,0.001165456,0.00005565518,0.00002527467,0.0000557161,0.0003291132,0.00001064335,0.0006111865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120334,"threshold_uncertainty_score":0.002597451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008607913285311455,"score_gpt":0.245262864678889,"score_spread":0.2366549513935775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}