{"id":"W2911149342","doi":"10.3390/cancers11010102","title":"Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Pannexin; Melanoma; Cancer research; Cell biology; Cell culture; Microphthalmia-associated transcription factor; Carbenoxolone; Biology; Melanocyte; Cell growth; Chemistry; Intracellular; Gap junction; Connexin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008658,0.0003037948,0.0002351013,0.0001549961,0.0001084211,0.0001988281,0.0001113835,0.0002189937,0.001821495],"category_scores_gemma":[0.00007644097,0.00007531425,0.0001629359,0.0001049856,0.0001125989,0.0001537174,0.0001274149,0.0005051324,0.0002893277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002152113,"about_ca_system_score_gemma":0.0001976645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008503177,"about_ca_topic_score_gemma":0.001324425,"domain_scores_codex":[0.999891,0.00001823724,0.00001010589,0.00002566625,0.0000309273,0.00002407793],"domain_scores_gemma":[0.9999478,0.00001087656,0.00001101631,0.000007016785,0.000006282371,0.00001705044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007055313,0.0000431001,0.0001225217,0.00003295954,0.000005107119,0.00002839176,0.00001173734,0.00004280692,0.9983387,0.00003902253,0.00008553913,0.001179536],"study_design_scores_gemma":[0.00002385796,0.0006060295,0.005352593,0.000005114573,0.00001731575,0.0001908231,0.00003408465,0.0008768791,0.9890755,0.00002748476,0.003787724,0.000002669266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937994,0.002900541,0.001055061,0.0001384491,0.00004466521,0.00003655523,0.0002989784,0.000104797,0.001621581],"genre_scores_gemma":[0.9944858,0.001335635,0.0006678237,0.00004643872,0.000006805077,0.00002990775,0.0004479272,0.00001426965,0.002965501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821495,"threshold_uncertainty_score":0.006093502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322450785504673,"score_gpt":0.2274129851120253,"score_spread":0.2141884772569785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}