{"id":"W2911151820","doi":"10.1101/522607","title":"Induction of an alternative 5’ leader enhances translation of <i>Inpp5e</i> and resistance to oncolytic virus infection","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique; McGill University; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa; Terry Fox Research Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Oncolytic virus; Biology; Innate immune system; Herpes simplex virus; Translation (biology); Virus; Virology; Vaccinia; Messenger RNA; Cell biology; Immune system; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179071,0.0002631673,0.0002313286,0.0001124579,0.000124033,0.000350546,0.0001688597,0.0002275403,0.001048885],"category_scores_gemma":[0.0002113698,0.0001223425,0.0002357601,0.00008571729,0.0002677997,0.0001421057,0.0002122439,0.0005484437,0.0004312573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003799932,"about_ca_system_score_gemma":0.0001521422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000581157,"about_ca_topic_score_gemma":0.0005594888,"domain_scores_codex":[0.9998127,0.00005102725,0.00002138219,0.00003391746,0.00003711321,0.00004406756],"domain_scores_gemma":[0.9998253,0.0000591354,0.00004718779,0.00002842461,0.00001347802,0.00002646957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007138893,0.00001340022,0.00007453174,0.000009809142,0.000001869396,0.00001601677,0.000007482791,0.00002860361,0.9994732,0.00005921523,0.00002412445,0.000220416],"study_design_scores_gemma":[0.000004631442,0.00008116068,0.0008576405,0.000001759945,0.000003062528,0.00004747479,0.000008988487,0.0004212563,0.9976987,0.00001558457,0.0008579588,0.000001752393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954194,0.0003719285,0.00254692,0.00008542013,0.00003606486,0.00002139452,0.0003336264,0.00006306408,0.00112221],"genre_scores_gemma":[0.9948573,0.0001459104,0.002332028,0.00005265146,0.0000107243,0.00001589543,0.0007570622,0.0000682746,0.001760228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048885,"threshold_uncertainty_score":0.003508925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330547111162862,"score_gpt":0.2831718279465967,"score_spread":0.2598663568349681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}