{"id":"W2911158691","doi":"10.1136/annrheumdis-2018-214930","title":"Altered DNA methylation in children born to mothers with rheumatoid arthritis during pregnancy","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; ReumaNederland; Arthritis Society; Erasmus Universiteit Rotterdam; ZonMw; European Commission; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society","keywords":"Medicine; DNA methylation; CpG site; Pregnancy; Methylation; Population; Rheumatoid arthritis; Confounding; Immunology; Internal medicine; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000959802,0.0001426898,0.0003515136,0.0001386374,0.00003576404,0.00001101288,0.000146075,0.00003553783,0.0001775078],"category_scores_gemma":[0.0003380693,0.00009316985,0.0001049082,0.0003064607,0.00005159511,0.0001547187,0.0000416154,0.0000769761,0.00004119821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000188456,"about_ca_system_score_gemma":0.0001229409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006246776,"about_ca_topic_score_gemma":0.000007713948,"domain_scores_codex":[0.9987667,0.00007124543,0.0003622301,0.0001970516,0.0003609338,0.0002418835],"domain_scores_gemma":[0.998925,0.00006154631,0.0001991757,0.0005668586,0.00006174455,0.0001857256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005673087,0.0007080262,0.8922296,0.0008595742,0.0004574913,0.000004208484,0.002357614,0.0003893203,0.001063661,0.0002093266,0.0006277864,0.100526],"study_design_scores_gemma":[0.001847635,0.0001471329,0.9704322,0.02060343,0.0000225433,0.00003244384,0.0001182268,0.00004915915,0.006370915,0.0002463969,0.0000151234,0.0001147537],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921847,0.004224142,0.00003183729,0.00182798,0.0000587147,0.001192109,0.00003349877,0.00003463266,0.0004123699],"genre_scores_gemma":[0.9975083,0.001855478,0.00007681185,0.0002431006,0.000009745676,0.00005630308,0.00001406723,0.00002220526,0.0002139469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1004113,"threshold_uncertainty_score":0.3799356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546259548283343,"score_gpt":0.2774556132014548,"score_spread":0.2619930177186214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}