{"id":"W2911232307","doi":"10.1016/j.neurobiolaging.2019.01.010","title":"Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease","year":2019,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Island University; Simon Fraser University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC","keywords":"Circadian rhythm; PER2; Neuroscience; Electroencephalography; Non-rapid eye movement sleep; Sleep deprivation; Psychology; Alzheimer's disease; Disease; Medicine; Internal medicine; Endocrinology; Circadian clock; CLOCK","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028793,0.0001438167,0.0002542505,0.0001159495,0.00004405184,0.000008282645,0.0001773828,0.00006887792,0.000008683742],"category_scores_gemma":[0.00006455801,0.0001140224,0.00006550611,0.0001421429,0.0002440519,0.0001257253,0.00009400318,0.0002462313,0.000005729029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007029952,"about_ca_system_score_gemma":0.00005821145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000183715,"about_ca_topic_score_gemma":0.000002077117,"domain_scores_codex":[0.9987615,0.000241883,0.0002142029,0.0004168268,0.00009888545,0.0002667377],"domain_scores_gemma":[0.9991035,0.0002588547,0.0001499671,0.0004037362,0.00001759754,0.00006636738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001004636,0.00006981628,0.002268608,0.00001366643,0.000005964292,0.000008519576,0.0007023704,0.0007247324,0.9947878,0.001041377,0.00002447613,0.0002522187],"study_design_scores_gemma":[0.0007665928,0.00012832,0.06221493,0.00002420253,0.00003608054,0.0000242516,0.00006646096,0.008313451,0.9280468,0.0001662662,0.00003622166,0.0001764818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980679,0.0001036902,0.00001726392,0.0004653194,0.0001287426,0.0003190393,0.00004470828,0.00001879193,0.0008345201],"genre_scores_gemma":[0.9992586,0.00005088715,0.00003143815,0.000540344,0.00001043421,0.000006525498,0.000001451459,0.00001488554,0.00008536917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06674104,"threshold_uncertainty_score":0.46497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03257944394918002,"score_gpt":0.2525990958377501,"score_spread":0.2200196518885701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}