{"id":"W2911267336","doi":"10.1038/npg.els.0001893","title":"Li–Fraumeni Syndrome","year":2001,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Li–Fraumeni syndrome; Germline; Germline mutation; Cancer; Cancer syndrome; Phenotype; Identification (biology); Genetics; Gene; Biology; Medicine; Mutation; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003006661,0.0003098132,0.0007007575,0.0006302889,0.00005645714,0.00001076635,0.0004092812,0.0003617668,0.009405845],"category_scores_gemma":[0.0002865445,0.0002602281,0.0001840444,0.000921548,0.0006910866,0.00004946087,0.00009205334,0.0003096354,0.0004169357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004828999,"about_ca_system_score_gemma":0.0009934197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007546968,"about_ca_topic_score_gemma":0.0001071461,"domain_scores_codex":[0.997606,0.00004279787,0.0004156292,0.0005885382,0.0009303762,0.000416694],"domain_scores_gemma":[0.998753,0.00004761286,0.0003731391,0.0004908656,0.0000416583,0.0002937025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000137147,0.0001374066,0.003542936,0.0002377622,0.0001264853,0.0002565876,0.0001150091,0.00001012177,0.0001033432,0.0001619668,0.9910943,0.004200369],"study_design_scores_gemma":[0.0005544355,0.0004767262,0.0006501353,0.000754385,0.0001207409,0.000197173,0.00009459051,0.00001315409,0.00004085458,0.0000540173,0.9967559,0.0002878805],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.002025787,0.01271727,0.0001322375,0.0004108019,0.001487712,0.0005068675,0.0000346107,0.0001902013,0.9824945],"genre_scores_gemma":[0.003274522,0.01535018,0.004048677,0.0004351701,0.0008634241,0.00003409345,0.00002660498,0.0003149168,0.9756524],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.008988908,"threshold_uncertainty_score":0.999985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531101631206551,"score_gpt":0.2682264078881013,"score_spread":0.2529153915760358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}