{"id":"W2911277207","doi":"10.1016/j.bpj.2018.11.852","title":"Structural Insights into Recognition of Ryanodine Receptors by PKA","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Phosphorylation; Ryanodine receptor 2; RYR1; Chemistry; Receptor; Cell biology; Intracellular; Biophysics; Protein kinase A; Gene isoform; Substrate (aquarium); Biochemistry; Substrate-level phosphorylation; Kinase; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974224,0.0004167348,0.000434937,0.0001223254,0.0004042853,0.0005940571,0.0005777651,0.0005127576,0.001846525],"category_scores_gemma":[0.0002085364,0.0002876036,0.0003148753,0.00010339,0.000397545,0.0005758477,0.0002830507,0.001695554,0.0007393806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006081515,"about_ca_system_score_gemma":0.0004088187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009241971,"about_ca_topic_score_gemma":0.0008625334,"domain_scores_codex":[0.9999257,0.00001072955,0.000005053229,0.00001237054,0.00002528377,0.00002083609],"domain_scores_gemma":[0.9999205,0.00002421257,0.00001451178,0.00000630621,0.000009862423,0.00002452617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005643346,0.0001223714,0.0004397058,0.0002095902,0.00002031901,0.0009653915,0.0001735343,0.005618358,0.9722148,0.01337516,0.0008498208,0.005446671],"study_design_scores_gemma":[0.0002296833,0.0005525738,0.005773531,0.00007421414,0.00007057562,0.002418383,0.0007338265,0.05545379,0.8960734,0.01022536,0.02830833,0.00008634332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658039,0.005006137,0.01479235,0.004302451,0.0003229607,0.00004170684,0.0003572,0.0002458906,0.009127523],"genre_scores_gemma":[0.9893505,0.003690524,0.003602717,0.0004057369,0.00007798138,0.00001347547,0.0003372247,0.00002042874,0.002501483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846525,"threshold_uncertainty_score":0.006177247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009775906754392391,"score_gpt":0.2292590780223847,"score_spread":0.2194831712679923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}