{"id":"W2911283542","doi":"10.1080/19491034.2019.1578600","title":"Exonuclease domain mutants of yeast <i>DIS3</i> display genome instability","year":2019,"lang":"en","type":"article","venue":"Nucleus","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta; BC Cancer Agency","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Exosome complex; Biology; Exonuclease; Genetics; Genome instability; Point mutation; Mitosis; Cell biology; RNA; Mutation; Non-coding RNA; Gene; DNA; Polymerase; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007564975,0.0006273292,0.0001784177,0.0002011257,0.0001908361,0.00023012,0.0002217079,0.0002418122,0.002377416],"category_scores_gemma":[0.0001076126,0.0001744413,0.0003033246,0.0001799218,0.000338161,0.00012602,0.0002448761,0.0005205513,0.001002424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004227877,"about_ca_system_score_gemma":0.000232122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591182,"about_ca_topic_score_gemma":0.002778098,"domain_scores_codex":[0.999921,0.00001005619,0.00001101493,0.00001987669,0.00002451954,0.00001354064],"domain_scores_gemma":[0.9998053,0.00003878498,0.00007189433,0.00002468153,0.00001410943,0.00004529137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005933434,0.0000083824,0.0001180843,0.00001651084,0.000003910126,0.00007071628,0.000006647042,0.00003547194,0.9989901,0.0001211956,0.00003930485,0.0005303808],"study_design_scores_gemma":[0.000007963607,0.0000416774,0.002480937,0.000003188462,0.000008557035,0.0004694171,0.0000173788,0.0003565172,0.9945046,0.00004530991,0.002060121,0.000004346373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808143,0.0004670698,0.01217358,0.0001548577,0.00006529899,0.00004379375,0.002279874,0.0004798209,0.003521502],"genre_scores_gemma":[0.9871392,0.0002232303,0.004598297,0.0000620124,0.000008302462,0.0000314735,0.002782081,0.0002831673,0.004872114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002377416,"threshold_uncertainty_score":0.007953286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007313859500598484,"score_gpt":0.2404160789681778,"score_spread":0.2331022194675793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}