{"id":"W2911283542","doi":"10.1080/19491034.2019.1578600","title":"Exonuclease domain mutants of yeast <i>DIS3</i> display genome instability","year":2019,"lang":"en","type":"article","venue":"Nucleus","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta; BC Cancer Agency","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Exosome complex; Biology; Exonuclease; Genetics; Genome instability; Point mutation; Mitosis; Cell biology; RNA; Mutation; Non-coding RNA; Gene; DNA; Polymerase; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984531,0.0001036418,0.0001454864,0.00002513037,0.00003562661,0.0000133954,0.000227697,0.00008653773,0.0001726492],"category_scores_gemma":[0.00005047948,0.00009335313,0.00008570449,0.00007765427,0.00008173569,0.000004731666,0.0001491376,0.00008171484,0.0001171915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001612642,"about_ca_system_score_gemma":0.00005515583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004888161,"about_ca_topic_score_gemma":0.00002659611,"domain_scores_codex":[0.9990602,0.00004772978,0.0001732576,0.0002782573,0.0001717703,0.0002687421],"domain_scores_gemma":[0.9992681,0.000006745957,0.00005374352,0.0004894405,0.00005610177,0.0001258494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001606204,0.00008073282,0.01013411,0.00003742512,0.00002150452,0.000004101625,0.00004447101,0.00001100614,0.9881229,0.0001143514,0.00008619,0.00118253],"study_design_scores_gemma":[0.004238683,0.001610691,0.3437878,0.00006156771,0.00002544445,0.00004427721,0.0007170502,0.0003382651,0.5182745,0.0003681706,0.1297275,0.0008060306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941002,0.0001153492,0.00006237878,0.00004239829,0.00006355804,0.0001996923,0.0000945122,0.000008277279,0.005313682],"genre_scores_gemma":[0.998537,0.00003116014,0.0003622998,0.0001023368,0.00005842599,0.000004381597,0.00003715598,0.00002025141,0.0008469559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4698485,"threshold_uncertainty_score":0.380683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007313859500598484,"score_gpt":0.2404160789681778,"score_spread":0.2331022194675793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}