{"id":"W2911294343","doi":"10.1093/aje/kwz005","title":"Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions","year":2019,"lang":"en","type":"review","venue":"American Journal of Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sociale en Geesteswetenschappen, NWO; Core Research for Evolutional Science and Technology; Fondo Nacional de Desarrollo Científico y Tecnológico; Institute of Genetics; School of Medicine, University of California, Irvine; School of Medicine, University of North Carolina at Chapel Hill; National Institute on Minority Health and Health Disparities; National Center on Minority Health and Health Disparities; Center for Information Technology; National Institute of Dental and Craniofacial Research; National Cancer Institute; National Eye Institute; NIH Office of the Director; National Institute on Aging; NIHR Barts Biomedical Research Centre, Queen Mary University of London; Faculty of Medicine and Health, University of Sydney; NIHR Leicester Biomedical Research Centre; Institute of Medical Science, University of Tokyo; School of Public Health, Imperial College London; Tongji Medical College, Huazhong University of Science and Technology; National Key Research and Development Program of China; Medicinska fakulteten, Umeå Universitet; RIKEN; Program for New Century Excellent Talents in University; Faculty of Science, National University of Singapore; European Research Council; Biotechnology and Biological Sciences Research Council; Fifth Framework Programme; Université de Lille; Sixth Framework Programme; University of California, Irvine; Graduate School of Public Health, University of Pittsburgh; Directorate for Biological Sciences; National University of Singapore; National Institutes of Health; Action on Hearing Loss; Amsterdam Neuroscience; National Institute of Diabetes and Digestive and Kidney Diseases; San Diego State University; Kaiser Foundation Research Institute; MedStar Health Research Institute; UK Dementia Research Institute; Kela; Terveyden ja hyvinvoinnin laitos; Huazhong University of Science and Technology; Novo Nordisk Foundation Center for Basic Metabolic Research; National University Health System; Amgen; University of Kelaniya; Houston Methodist Research Institute; Centre Hospitalier Universitaire de Rennes; U.S. Environmental Protection Agency; Skånes universitetssjukhus; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; Diabetesliitto; Tampereen Tuberkuloosisäätiö; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; European Commission; University of North Carolina at Chapel Hill; Ministério da Educação; National Institute of Neurological Disorders and Stroke; Paavo Nurmen Säätiö; Ministerie van Economische Zaken; Technische Universität München; Universidade de São Paulo; Genome Institute of Singapore; University of Miami; Georgetown University; Sydäntutkimussäätiö; Universitair Medisch Centrum Groningen; Umeå Universitet; Ministério da Saúde; Barts and The London School of Medicine and Dentistry; Emil Aaltosen Säätiö; Servier; Ministry of Economic Affairs; Stockholms Läns Landsting; University of Alabama; Associação Brasileira de Saúde Coletiva; National Center for Advancing Translational Sciences; Päivikki ja Sakari Sohlbergin Säätiö; University of Southern California; Kuopion Yliopistollinen Sairaala; Juho Vainion Säätiö; Centre for Cognitive Ageing and Cognitive Epidemiology; Medical Research Council; Hjärt-Lungfonden; Novo Nordisk; Hebrew University of Jerusalem; Hjartavernd; Jackson State University; Tekes; Itä-Suomen Yliopisto; Southern California Clinical and Translational Science Institute; Faculty of Health and Medical Sciences, University of Western Australia; Lunds Universitet; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Ministero della Salute; Wake Forest School of Medicine; National Human Genome Research Institute; Japan Science and Technology Agency; MRC-PHE Centre for Environment and Health; Fundação de Amparo à Pesquisa do Estado de São Paulo; Fondation de France; Japan Agency for Medical Research and Development; Signe ja Ane Gyllenbergin Säätiö; Fédération Française de Cardiologie; U.S. National Library of Medicine; Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston; Erasmus Medisch Centrum; Loyola University Chicago Stritch School of Medicine; Turun Yliopistollinen Keskussairaala; Capital Medical University; Universität Heidelberg; Bundesministerium für Bildung und Forschung; Academy of Finland; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Russian Foundation for Basic Research; School of Medicine, University of Maryland; University of Alabama at Birmingham; Imperial College London; Public Health England; Foundation for Cardiovascular Research; ZonMw; Stiftelsen för Strategisk Forskning; Institut National de la Santé et de la Recherche Médicale; Centre for Medical Systems Biology; Washington University in St. Louis; Minerva Foundation; Environmental Protection Agency; National Institute on Deafness and Other Communication Disorders; Agency for Science, Technology and Research; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Northwestern University; University of Washington; University of Bristol; Sanofi; University of Oxford; University of Leicester; Brown University; Kidney Research UK; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Research Foundation Singapore; Erasmus Universitair Medisch Centrum Rotterdam; British Heart Foundation; Eesti Teadusagentuur; Office of Dietary Supplements; National Research Foundation; Diabetes Fonds; National Science Foundation, United Arab Emirates; National Institute for Health and Care Research; Universidade Federal de Pelotas; School of Medicine, University of Virginia; University of Glasgow; Topcon Corporation; Duke-NUS Medical School; Brigham and Women's Hospital; Tulane University; Les Laboratories Pierre Fabre; Scottish Government; European Regional Development Fund; Karolinska Institutet; School of Public Health, University of Michigan; Pfizer; Imperial College Healthcare NHS Trust; Universität Greifswald; Scottish Government Health and Social Care Directorate; Diabetes Research Center; National Institute of Nursing Research; Universiteit Leiden; Hankuk University of Foreign Studies; Wake Forest University; Hadassah Medical Organization; Home Office; University of Dundee; Johns Hopkins University; Wellcome Trust; National Natural Science Foundation of China; Lee Kong Chian School of Medicine, Nanyang Technological University; School of Medicine, Boston University; Yrjö Jahnssonin Säätiö; Harvard University; Department of Science and Technology, Philippines; Intramural Research Program; Queen Mary University of London; University of Pittsburgh; University of Bern; Cancer Research UK; Vetenskapsrådet; Scottish Funding Council; Ministry of Education, Culture, Sports, Science and Technology; Helsingin ja Uudenmaan Sairaanhoitopiiri; World Health Organization; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Kaiser Permanente; Mashhad University of Medical Sciences; Massachusetts Institute of Technology; Novartis Pharmaceuticals Corporation; National Center for Research Resources; International Development Research Centre; National Center for Global Health and Medicine; National Institute for Health Research Health Protection Research Unit; Centre National de la Recherche Scientifique; Rijksuniversiteit Groningen; National Medical Research Council; Suomen Kulttuurirahasto; American Heart Association; School of Medicine, Vanderbilt University; Case Western Reserve University; School of Medicine, Johns Hopkins University; University of Minnesota; Wellcome; School of Medicine, Case Western Reserve University; Ministry of Cultural Affairs; Broad Institute; Leids Universitair Medisch Centrum; Helmholtz Zentrum München; Helsingin Yliopisto; Torsten Söderbergs Stiftelse; Hrvatska Zaklada za Znanost; Age UK; Foundation for the National Institutes of Health; Ministry of Education and Science; Nanyang Technological University; Société Francophone du Diabète; National Institute of Biomedical Innovation; Eli Lilly and Company; Siemens; Nierstichting; Tongji University; Association Diabète Risque Vasculaire; University of Edinburgh; Knut och Alice Wallenbergs Stiftelse; Biomedical Research Council; Seventh Framework Programme; National Heart, Lung, and Blood Institute; AstraZeneca; Women's Health Initiative; Vanderbilt University; Feinberg School of Medicine; Turun Yliopisto; Yale University; Loyola University Chicago","keywords":"Genome-wide association study; Gene; Genetics; Alcohol; Biology; Genetic association; Computational biology; Medicine; Genotype; Single-nucleotide polymorphism; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004893761,0.0007452186,0.001048034,0.001702287,0.00090452,0.0009252117,0.000856857,0.0008302068,0.001284692],"category_scores_gemma":[0.007051195,0.0006077807,0.002830732,0.002638773,0.0004604226,0.0004895348,0.00131278,0.0008943582,0.0001373955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004622531,"about_ca_system_score_gemma":0.0007785358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007297308,"about_ca_topic_score_gemma":0.01456159,"domain_scores_codex":[0.9941283,0.003490134,0.0004677757,0.001339751,0.0003009423,0.0002731641],"domain_scores_gemma":[0.9939783,0.003011607,0.001214837,0.00120239,0.0003458318,0.0002469894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00175191,0.00008772072,0.9646981,0.000219003,0.0126426,0.0007462539,0.0003284989,0.00125727,0.009269994,0.0004038396,0.0002787067,0.008316026],"study_design_scores_gemma":[0.0002627978,0.00085091,0.9797662,0.00005068031,0.009618223,0.0009562915,0.0001659531,0.00418809,0.001976539,0.0008285802,0.001296556,0.0000391877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9887875,0.002710042,0.007008126,0.0001484443,0.0000226865,0.0001007226,0.0007682964,0.00005007056,0.0004041595],"genre_scores_gemma":[0.9953195,0.0002130427,0.003793412,0.00005388047,0.00001273866,0.0000592986,0.0003850394,0.0000105938,0.0001524467],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007297308,"threshold_uncertainty_score":0.02588099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035918665991546,"score_gpt":0.4004278904077738,"score_spread":0.2968360238086191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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