{"id":"W2911295821","doi":"10.1074/jbc.ra118.007240","title":"Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate–induced activation of ATP8A2 dephosphorylation","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canadian Institutes of Health Research; Novo Nordisk Fonden; Lundbeckfonden; National Institutes of Health; Danmarks Frie Forskningsfond; Novo Nordisk","keywords":"Flippase; Dephosphorylation; Asparagine; Phospholipid; Chemistry; Biochemistry; Substrate (aquarium); Cell biology; Phosphorylation; Phosphatidylserine; Biology; Enzyme; Phosphatase; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988745,0.0005185286,0.0003522726,0.0001454816,0.0002030067,0.0004231786,0.0003277596,0.000381183,0.001263633],"category_scores_gemma":[0.000375949,0.0002055163,0.0003527541,0.0001693053,0.0002847092,0.0001918196,0.0003812201,0.0004793706,0.0008696956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667598,"about_ca_system_score_gemma":0.0002868623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155672,"about_ca_topic_score_gemma":0.0008605177,"domain_scores_codex":[0.9997911,0.00005375167,0.00003743278,0.00002975268,0.00005587626,0.00003207608],"domain_scores_gemma":[0.9996721,0.00007952305,0.00009086608,0.000029197,0.00002726994,0.0001011253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004450739,0.00006451195,0.0005579729,0.00005292684,0.00001845963,0.0005171801,0.00002490549,0.0003362163,0.9958561,0.0001666355,0.00004774434,0.001912287],"study_design_scores_gemma":[0.00006111104,0.0003189123,0.006520361,0.00001720504,0.00003232621,0.001309424,0.00005909296,0.002708594,0.9861127,0.00009590125,0.002746887,0.00001745937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954932,0.0005179967,0.002338278,0.00007592685,0.00003546914,0.00003027636,0.000325795,0.00006071854,0.001122267],"genre_scores_gemma":[0.9972801,0.0001728727,0.001430797,0.00003627999,0.000006697748,0.00001285679,0.000451327,0.00002633233,0.0005827477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263633,"threshold_uncertainty_score":0.004227221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01453254561408824,"score_gpt":0.2389793187547715,"score_spread":0.2244467731406833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}