{"id":"W2911427426","doi":"10.1016/j.ccell.2019.01.005","title":"Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of Environmental Health Sciences; European Hematology Association","keywords":"Carcinogenesis; Epigenetics; Biology; DNA methylation; Wnt signaling pathway; Gene silencing; Cancer research; Stem cell; Phenotype; Cell biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356066,0.0002034347,0.000170749,0.000203956,0.0001237005,0.0002209217,0.0001475614,0.0001897749,0.001245613],"category_scores_gemma":[0.000140365,0.0001263252,0.0001987068,0.0001058454,0.0001698816,0.0001475979,0.0002084969,0.0003101483,0.000215625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002814603,"about_ca_system_score_gemma":0.0002123078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009979127,"about_ca_topic_score_gemma":0.002515589,"domain_scores_codex":[0.9999198,0.00001162804,0.000007585106,0.00001951401,0.0000190259,0.00002240327],"domain_scores_gemma":[0.9998896,0.00001424166,0.00003097383,0.00002320189,0.000009558675,0.0000324374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001004691,0.0000154119,0.0004692776,0.000009559418,0.000004811905,0.00007400424,0.000009529589,0.0000413729,0.9981208,0.0002148654,0.00003858571,0.0009013847],"study_design_scores_gemma":[0.00001538278,0.000225895,0.01864434,0.000003078833,0.00001808815,0.0005222374,0.00003150378,0.001285871,0.9764569,0.0001758355,0.002615497,0.000005407407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967635,0.0006870475,0.001275577,0.00005506938,0.00001914411,0.000007841346,0.0002657853,0.00009033796,0.0008356321],"genre_scores_gemma":[0.9976898,0.0001840374,0.0003864217,0.00001809195,0.000003610787,0.000005637089,0.0002037779,0.00001231217,0.001496432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245613,"threshold_uncertainty_score":0.00416702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00859823346227199,"score_gpt":0.2347923986707708,"score_spread":0.2261941652084989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}