{"id":"W2911427426","doi":"10.1016/j.ccell.2019.01.005","title":"Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of Environmental Health Sciences; European Hematology Association","keywords":"Carcinogenesis; Epigenetics; Biology; DNA methylation; Wnt signaling pathway; Gene silencing; Cancer research; Stem cell; Phenotype; Cell biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343106,0.0001960953,0.0001745876,0.00003227336,0.00008646682,0.00003575295,0.000123237,0.0001267513,0.0001138553],"category_scores_gemma":[0.00001722413,0.000195819,0.00005402086,0.0000741069,0.0000283696,0.000007937873,0.00007251643,0.00006467889,0.0000182297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005625951,"about_ca_system_score_gemma":0.0001145102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003806277,"about_ca_topic_score_gemma":0.0001607803,"domain_scores_codex":[0.9988361,0.00005330152,0.0002200987,0.0004786492,0.0001425735,0.0002692657],"domain_scores_gemma":[0.999343,0.00003080261,0.0001050942,0.0003080949,0.0001120642,0.0001009814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002577748,0.00001939011,0.01021213,0.00008473577,0.000019064,0.000003219452,0.0002185503,0.0004766645,0.9852514,0.000005335886,0.00002662213,0.003657116],"study_design_scores_gemma":[0.000385169,0.0001800033,0.01077087,0.0000282681,0.00001931435,0.000004198893,0.0002979148,0.0001198556,0.9816304,0.00005734466,0.006224336,0.0002822923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886558,0.009616707,0.0003115905,0.00004542699,0.0003749264,0.0002952333,0.00001429062,0.00001601957,0.0006700261],"genre_scores_gemma":[0.9950026,0.002275564,0.0001545821,0.000114172,0.0001694352,0.00003472822,0.00004751342,0.00003302137,0.002168427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007341143,"threshold_uncertainty_score":0.7985268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00859823346227199,"score_gpt":0.2347923986707708,"score_spread":0.2261941652084989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}