{"id":"W2911434758","doi":"10.1111/bjd.17628","title":"Efficacy and safety of mirikizumab ( <scp>LY</scp> 3074828) in the treatment of moderate‐to‐severe plaque psoriasis: results from a randomized phase <scp>II</scp> study","year":2019,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Innovaderm (Canada)","funders":"Eli Lilly and Company","keywords":"Medicine; Placebo; Psoriasis Area and Severity Index; Psoriasis; Adverse effect; Internal medicine; Clinical endpoint; Gastroenterology; Plaque psoriasis; Randomized controlled trial; Surgery; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002976531,0.001146896,0.002140941,0.0002800288,0.0003484713,0.0007962676,0.0007034279,0.001188546,0.003991463],"category_scores_gemma":[0.001669434,0.0005846541,0.001852023,0.0002819077,0.0007192307,0.0006040944,0.0002887352,0.00214845,0.0007935317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005026399,"about_ca_system_score_gemma":0.000970086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000386467,"about_ca_topic_score_gemma":0.0007364317,"domain_scores_codex":[0.9990471,0.0006214444,0.00006689129,0.0001053619,0.00008934669,0.00006983116],"domain_scores_gemma":[0.9983632,0.0004239728,0.0004967823,0.0001196609,0.0001129933,0.0004835101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9590337,0.007859737,0.001574609,0.0006470266,0.001033716,0.00003885703,0.00005887173,0.0002827371,0.01018913,0.00004336841,0.0008530727,0.01838511],"study_design_scores_gemma":[0.8769511,0.113898,0.006605548,0.00003521262,0.0006464474,0.00009102756,0.00001336379,0.0002814745,0.0008723378,0.00005530096,0.0005365924,0.00001365018],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914255,0.00364516,0.0005125799,0.0004308773,0.0001696104,0.001877714,0.0008593628,0.00006457311,0.001014641],"genre_scores_gemma":[0.9923717,0.001980282,0.0009469415,0.0005585505,0.0002689249,0.001751223,0.00107777,0.00002137917,0.001023322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003991463,"threshold_uncertainty_score":0.01574165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353701810919208,"score_gpt":0.251430133745222,"score_spread":0.2378931156360299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}