{"id":"W2911454155","doi":"10.1101/537431","title":"Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; Dalhousie University","funders":"Israel Science Foundation; European Commission; National Institutes of Health; National Science Foundation","keywords":"Blood–brain barrier; Neuroscience; Signal transduction; Transforming growth factor; Medicine; Biology; Psychology; Endocrinology; Central nervous system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005651801,0.0005406881,0.0006804654,0.0006351689,0.0002453842,0.0001529735,0.0002799944,0.0004804927,0.00004988669],"category_scores_gemma":[0.0005923908,0.0005685919,0.00011881,0.0008416103,0.0001933159,0.0005833789,0.0004225675,0.0009998539,0.000009393934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002491866,"about_ca_system_score_gemma":0.0003461788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000948852,"about_ca_topic_score_gemma":0.000004539363,"domain_scores_codex":[0.996797,0.0002886303,0.0006744735,0.001270184,0.0004835286,0.0004861512],"domain_scores_gemma":[0.997964,0.0003136225,0.0006532066,0.0007096106,0.0002296365,0.000129977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005996168,0.00003955403,0.0124619,0.0004757189,0.00005042853,0.000006380547,0.00005505254,0.001060233,0.9854768,0.0002025163,0.00009482043,0.00001662268],"study_design_scores_gemma":[0.00107539,0.0001418453,0.04261324,0.0004877851,0.0001172663,1.037997e-7,0.00002846939,0.0009019073,0.9531833,0.000007458005,0.0008814056,0.0005618162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947627,0.000727426,0.0006119877,0.0003194102,0.002621573,0.0006940753,0.0000646534,0.0001708951,0.00002732873],"genre_scores_gemma":[0.9986924,0.0002030779,0.0001763042,0.0003695741,0.0003869646,0.00007071094,5.132858e-7,0.00007912518,0.0000213598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03229349,"threshold_uncertainty_score":0.9996765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093095011405135,"score_gpt":0.2230697514915995,"score_spread":0.2021388013775481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}