{"id":"W2911467060","doi":"10.1186/s13046-018-0999-5","title":"Therapeutic impact of Nintedanib with paclitaxel and/or a PD-L1 antibody in preclinical models of orthotopic primary or metastatic triple negative breast cancer","year":2019,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Triple-negative breast cancer; Paclitaxel; Medicine; Nintedanib; Oncology; Breast cancer; Internal medicine; Triple negative; Metastatic breast cancer; Antibody; Docetaxel; Cancer; Cancer research; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003401009,0.0008864572,0.0008218913,0.0006010563,0.0002608394,0.0004716006,0.0004648806,0.0003641852,0.001392174],"category_scores_gemma":[0.0001454517,0.0002358008,0.0004565863,0.0004026823,0.0003832428,0.0003615804,0.0001667615,0.001132908,0.0002720807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006901313,"about_ca_system_score_gemma":0.0008019041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002005871,"about_ca_topic_score_gemma":0.004767612,"domain_scores_codex":[0.9998032,0.00003907377,0.00001346431,0.00003116772,0.00003918845,0.00007389767],"domain_scores_gemma":[0.9998239,0.00002443663,0.0000411096,0.00001414057,0.00001624205,0.00008029473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01103336,0.007956818,0.0009158948,0.0004020793,0.0001308541,0.0001773238,0.0001250995,0.002282472,0.9614823,0.0001800537,0.0008221322,0.0144916],"study_design_scores_gemma":[0.001294589,0.07500269,0.006469478,0.00003170372,0.0002523919,0.0004392893,0.0001082371,0.003215301,0.9090572,0.00006367872,0.004035295,0.00003018591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948924,0.001947727,0.0005882664,0.0001459993,0.0001045889,0.000156801,0.0005564123,0.0001049523,0.001502735],"genre_scores_gemma":[0.994002,0.001772141,0.001354048,0.00006075186,0.00002917286,0.0001815202,0.0007913941,0.00002853447,0.00178042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005871,"threshold_uncertainty_score":0.005007267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2322888676423589,"score_gpt":0.569873010385426,"score_spread":0.3375841427430671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}