{"id":"W2911469917","doi":"10.1021/jacs.8b13049","title":"Two-Enzyme Pathway Links <scp>l</scp>-Arginine to Nitric Oxide in <i>N</i>-Nitroso Biosynthesis","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Alfred P. Sloan Foundation","keywords":"Chemistry; Nitric oxide; Nitroso; Biosynthesis; Arginine; Streptozocin; Enzyme; Arginase; Biochemistry; Nitric oxide synthase; Nitroso Compounds; Amino acid; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002831075,0.0001637465,0.0003392663,0.00002944864,0.00003682482,0.00001937554,0.0006149843,0.0001012147,0.000003946822],"category_scores_gemma":[0.0003051214,0.000115395,0.0004406566,0.0005387709,0.000131507,0.000005884434,0.0002257662,0.0004275176,0.00001740866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003791345,"about_ca_system_score_gemma":0.0001047182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003319919,"about_ca_topic_score_gemma":9.68427e-7,"domain_scores_codex":[0.9988241,0.00005141697,0.0003737108,0.0002185721,0.0002295151,0.000302687],"domain_scores_gemma":[0.998859,0.0001004368,0.0004074083,0.000393899,0.00008841026,0.0001508266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001304158,0.00009098445,0.004858518,0.000004317533,0.00004284271,4.588997e-7,0.00004812684,0.00003754334,0.9866109,0.00001040262,0.007122944,0.001159901],"study_design_scores_gemma":[0.000452947,0.00005095875,0.008197965,0.00001660719,0.000025428,0.00002242666,0.0003728696,0.00002331291,0.9273388,0.00005451905,0.06336354,0.00008058662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979582,0.0003476527,0.0002306271,0.000947962,0.00005986165,0.0001394626,0.00002253812,0.000004957242,0.0002886715],"genre_scores_gemma":[0.9903826,0.0001503685,0.004865082,0.003781786,0.000391316,0.000008515473,0.000004251761,0.0000233226,0.0003928338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05927208,"threshold_uncertainty_score":0.470567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005487360446684094,"score_gpt":0.2339708434756606,"score_spread":0.2284834830289765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}