{"id":"W2911469917","doi":"10.1021/jacs.8b13049","title":"Two-Enzyme Pathway Links <scp>l</scp>-Arginine to Nitric Oxide in <i>N</i>-Nitroso Biosynthesis","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Alfred P. Sloan Foundation","keywords":"Chemistry; Nitric oxide; Nitroso; Biosynthesis; Arginine; Streptozocin; Enzyme; Arginase; Biochemistry; Nitric oxide synthase; Nitroso Compounds; Amino acid; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023856,0.0007137583,0.0003167499,0.0002368373,0.000496558,0.000637955,0.0005462114,0.0009326258,0.001656135],"category_scores_gemma":[0.0002257564,0.0001766176,0.0004762427,0.0001466809,0.0004624384,0.0008102916,0.0006056929,0.0011741,0.001190109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007450578,"about_ca_system_score_gemma":0.0006747941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006866945,"about_ca_topic_score_gemma":0.0008740458,"domain_scores_codex":[0.9997374,0.0000457381,0.00001554312,0.000082245,0.00006633298,0.0000526609],"domain_scores_gemma":[0.9998171,0.00002099062,0.00004664699,0.00002741649,0.00003613986,0.00005179102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001496499,0.00008274845,0.0009054354,0.0001766597,0.00001664942,0.0005805891,0.00005299776,0.0002855798,0.984086,0.006560679,0.0002575664,0.006845335],"study_design_scores_gemma":[0.00002438506,0.0003787113,0.002769186,0.00001727676,0.00002281055,0.001262816,0.00007349857,0.004515235,0.9724017,0.003221335,0.01528663,0.00002648097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7170417,0.009527502,0.2461016,0.003219344,0.001512351,0.0003539461,0.0005817359,0.0008678521,0.02079403],"genre_scores_gemma":[0.9278679,0.002377454,0.05607212,0.0003042553,0.00005710379,0.00008354542,0.0004867671,0.000049547,0.01270134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001656135,"threshold_uncertainty_score":0.005540371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005487360446684094,"score_gpt":0.2339708434756606,"score_spread":0.2284834830289765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}