{"id":"W2911490798","doi":"10.1016/s1470-2045(18)30860-x","title":"Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":397,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Bayer Fund","keywords":"Abiraterone acetate; Medicine; Prostate cancer; Prednisone; Abiraterone; Placebo; Urology; Radium-223; Internal medicine; Castration; Prednisolone; Oncology; Cancer; Androgen deprivation therapy; Bone metastasis; Hormone; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001731237,0.002347192,0.004361997,0.0007180825,0.0006199728,0.001452771,0.0011433,0.002672298,0.0071424],"category_scores_gemma":[0.001883949,0.001052142,0.003134132,0.0007285172,0.00189835,0.001068957,0.0005307859,0.004554801,0.001679379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007249521,"about_ca_system_score_gemma":0.001462061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002013048,"about_ca_topic_score_gemma":0.003771454,"domain_scores_codex":[0.9992124,0.0004191219,0.00004851618,0.000134094,0.00005786555,0.0001280116],"domain_scores_gemma":[0.9990096,0.0003176868,0.0002006481,0.00008828427,0.00004988675,0.0003337703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9882812,0.002124493,0.0001566475,0.0004028087,0.0007680286,0.00002082952,0.00003524228,0.0001653363,0.001163826,0.0000443989,0.0003526625,0.006484545],"study_design_scores_gemma":[0.9670097,0.03151453,0.0005379196,0.0000183999,0.0003239798,0.00001807005,0.00001084943,0.0001084926,0.0001435689,0.00006235759,0.0002422833,0.00001000892],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777057,0.01093581,0.0008333814,0.001047875,0.001293645,0.003627092,0.001105298,0.0003558393,0.003095339],"genre_scores_gemma":[0.9833428,0.005497957,0.001138878,0.001339186,0.0007629613,0.00248229,0.0008993053,0.00005210454,0.004484497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0071424,"threshold_uncertainty_score":0.02389371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04740764339260094,"score_gpt":0.3646799658367788,"score_spread":0.3172723224441779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}