{"id":"W2911490798","doi":"10.1016/s1470-2045(18)30860-x","title":"Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":397,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Bayer Fund","keywords":"Abiraterone acetate; Medicine; Prostate cancer; Prednisone; Abiraterone; Placebo; Urology; Radium-223; Internal medicine; Castration; Prednisolone; Oncology; Cancer; Androgen deprivation therapy; Bone metastasis; Hormone; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008241965,0.0002362104,0.00131488,0.0001703551,0.00007531748,0.00002988273,0.00007971226,0.00009245238,0.0001492301],"category_scores_gemma":[0.00005701284,0.0001222629,0.00004242773,0.0002465689,0.0002147948,0.0001326728,0.00005250451,0.0002310948,0.000004644142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001790789,"about_ca_system_score_gemma":0.0005482538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002999663,"about_ca_topic_score_gemma":0.0009165573,"domain_scores_codex":[0.9981055,0.0002792534,0.0005072118,0.0003770461,0.0003004543,0.0004304887],"domain_scores_gemma":[0.9988095,0.0003418453,0.0002694989,0.0002722705,0.0001592782,0.0001475783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9865565,0.001369603,0.001783301,0.0002075269,0.0004744151,0.00004870662,0.001327772,0.00003668633,0.00354208,0.00001903001,0.0003658103,0.004268527],"study_design_scores_gemma":[0.9760144,0.01726254,0.003051037,0.0001778078,0.000395101,0.00001455814,0.0001799984,0.00007127198,0.001789079,0.00001601814,0.0008874238,0.0001408033],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824536,0.001067922,0.000005315525,0.002866053,0.0001100232,0.01289128,0.0004290408,0.00001947731,0.0001572936],"genre_scores_gemma":[0.9948187,0.0007931552,0.0002969808,0.0001593566,0.0001454428,0.002405794,0.0002049512,0.00002610042,0.001149554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01589294,"threshold_uncertainty_score":0.4985738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04740764339260094,"score_gpt":0.3646799658367788,"score_spread":0.3172723224441779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}