{"id":"W2911504902","doi":"10.1038/s41398-019-0396-7","title":"ADGRL3 (LPHN3) variants predict substance use disorder","year":2019,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Juvenile Justice and Delinquency Prevention; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Alliance for Research on Schizophrenia and Depression; University of Illinois at Chicago; European College of Neuropsychopharmacology; University of Kentucky; Stanford University; School of Medicine, New York University; Generalitat de Catalunya; European Regional Development Fund; European Commission; Eli Lilly and Company; U.S. Department of Justice; U.S. Department of Health and Human Services; Universidad del Norte; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; McGill University; Departament de Salut, Generalitat de Catalunya; Columbia University; University of California Berkeley; University of Illinois System; University of Pittsburgh; Office of Special Education Programs, Office of Special Education and Rehabilitative Services; School of Medicine, Duke University","keywords":"Attention deficit hyperactivity disorder; Substance abuse; Comorbidity; Conduct disorder; Psychiatry; Psychology; Clinical psychology; Pharmacogenomics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001117291,0.0001982382,0.000262319,0.0001134317,0.00007279399,0.00003454487,0.0000881679,0.00013944,0.003510887],"category_scores_gemma":[0.00001646088,0.0001923437,0.0001779778,0.0002869053,0.00004479487,0.0004885356,0.000005458794,0.0002928863,0.001048129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001697238,"about_ca_system_score_gemma":0.0001890368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002358726,"about_ca_topic_score_gemma":0.00009019037,"domain_scores_codex":[0.9984416,0.00003986599,0.0003194643,0.0003993308,0.0005327598,0.0002669753],"domain_scores_gemma":[0.9992139,0.00008984236,0.00008202958,0.0003859746,0.0001106831,0.0001175798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003200608,0.0005113104,0.9891831,0.00007759423,0.0001087164,0.000002158284,0.000131906,0.0003320231,0.0004306872,0.007388357,0.0009145542,0.0005995707],"study_design_scores_gemma":[0.003677199,0.00009297576,0.9849362,0.0001027803,0.0000965612,0.00004505748,0.0001703719,0.001578905,0.000002485044,0.001000867,0.008073683,0.0002228498],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802746,0.0006963522,0.004935021,0.006266133,0.001004182,0.000645934,0.00007215222,0.0001389737,0.005966697],"genre_scores_gemma":[0.9895065,0.00002344537,0.004907221,0.0007459605,0.0001842602,0.0000157462,0.000190549,0.00004914723,0.004377157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009231959,"threshold_uncertainty_score":0.9997297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02817966831406154,"score_gpt":0.2922603338465981,"score_spread":0.2640806655325366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}