{"id":"W2911504902","doi":"10.1038/s41398-019-0396-7","title":"ADGRL3 (LPHN3) variants predict substance use disorder","year":2019,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Juvenile Justice and Delinquency Prevention; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Alliance for Research on Schizophrenia and Depression; University of Illinois at Chicago; European College of Neuropsychopharmacology; University of Kentucky; Stanford University; School of Medicine, New York University; Generalitat de Catalunya; European Regional Development Fund; European Commission; Eli Lilly and Company; U.S. Department of Justice; U.S. Department of Health and Human Services; Universidad del Norte; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; McGill University; Departament de Salut, Generalitat de Catalunya; Columbia University; University of California Berkeley; University of Illinois System; University of Pittsburgh; Office of Special Education Programs, Office of Special Education and Rehabilitative Services; School of Medicine, Duke University","keywords":"Attention deficit hyperactivity disorder; Substance abuse; Comorbidity; Conduct disorder; Psychiatry; Psychology; Clinical psychology; Pharmacogenomics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001519204,0.0007336959,0.0003936536,0.000872599,0.0004213943,0.0008204154,0.0005979736,0.0005662728,0.002204719],"category_scores_gemma":[0.0051182,0.0002123048,0.001195212,0.0007983437,0.0003129629,0.0002822248,0.0007635251,0.0009614561,0.0003706453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005445755,"about_ca_system_score_gemma":0.0005777431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01455572,"about_ca_topic_score_gemma":0.01738287,"domain_scores_codex":[0.9990734,0.000482035,0.0000463645,0.0002528587,0.00007049349,0.00007487852],"domain_scores_gemma":[0.9984469,0.0008909635,0.0003117245,0.0001509437,0.0001032178,0.00009629736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006034416,0.00007644314,0.9563599,0.0000441581,0.0006119707,0.0001936493,0.0002192395,0.007521391,0.003789271,0.0006630752,0.0006936861,0.02922365],"study_design_scores_gemma":[0.0001285304,0.0002170881,0.8844314,0.00008481839,0.0006031668,0.000758301,0.0003111832,0.1066825,0.001481762,0.004098793,0.001165949,0.00003658397],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896429,0.0003155389,0.007996438,0.0002781375,0.000008072311,0.00003128647,0.0009526391,0.00009060814,0.0006844769],"genre_scores_gemma":[0.9955403,0.00006650251,0.003613518,0.00003390085,0.000004776587,0.00001587243,0.0005633289,0.00001393267,0.0001478746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01455572,"threshold_uncertainty_score":0.02894199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02817966831406154,"score_gpt":0.2922603338465981,"score_spread":0.2640806655325366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}